Ultra-Sensitive Iron-Doped Palladium Nanocrystals with Enhanced Hydroxyl Radical Generation for Chemo-/ Chemodynamic Nanotherapy

Xie Wensheng; Zhang Genpei; Guo ZhenhuLu JingsongYe JielinXu WanlingGao XiaohanYue KaiWei YenZhao Lingyun

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Ultra-Sensitive Iron-Doped Palladium Nanocrystals with Enhanced Hydroxyl Radical Generation for Chemo-/ Chemodynamic Nanotherapy

机译：Ultra-Sensitive Iron-Doped Palladium Nanocrystals with Enhanced Hydroxyl Radical Generation for Chemo-/ Chemodynamic Nanotherapy

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Chemodynamic therapy (CDT) is a novel therapeutic modality that employs Fenton or Fenton-like reaction to destroy cancer cells via the disproportionation of intratumoral hydrogen peroxide (H2O2) to the highly toxic hydroxyl radical (center dot OH) without external energy input. A highly efficient chemodynamic catalyst in tumor microenvironment (TME) is key to effective anti-tumor efficacy. Therefore, ultra-sensitive FePd-TPP/adriamycin (ADM) nanocrystals (NCs) are constructed via a simple thermal decomposition method with high catalytic efficiency for combined chemo-/chemodynamic cancer nanotherapy. These FePd-TPP/ADM NCs exhib high Fenton-reaction efficiency with a Michaelis-Menten constant (K-m) and maximum velocity (V-max) of 3.65 mm and 1.69 x 10(-9) m s(-1), respectively. The ab-initio molecular dynamics simulation based on density functional theory demonstrate that the repulsion effect between Pd and H atom contribute to the enhancement of the Fe2+ mediated Fenton oxidation. Moreover, the doping of Fe enables FePd-TPP/ADM NCs to be an efficient contrast agent for T-2-weighted magnetic resonance imaging. Finally, upon intravenous injection, the FePd-TPP/ADM NCs reveal synergistic tumor growth inhibition compared with chemotherapy and CDT alone. Considering the good biocompatibility and biosafety, this study may pave the way to design a theranostic nano-platform based on palladium nanoparticles for various catalytic applications.

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来源
《Advanced functional materials》 |2022年第12期|2107518.1-2107518.10|共10页
作者
Xie Wensheng; Zhang Genpei; Guo ZhenhuLu JingsongYe JielinXu WanlingGao XiaohanYue KaiWei YenZhao Lingyun;
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Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China|Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China;

Univ Sci & Technol Beijing, Sch Energy & Environm Engn, Beijing 100083, Peoples R China|Univ Sci & Technol Beijing, Shunde Grad Sch, Sch Energy & Environm Engn, Shunde 528399, Guangdong, Peoples R China;

Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R ChinaTsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China;

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正文语种英语
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adriamycin; chemodynamic catalysts; nanotherapy; ultrasensitive FePd nanocrystals;

Ultra-Sensitive Iron-Doped Palladium Nanocrystals with Enhanced Hydroxyl Radical Generation for Chemo-/ Chemodynamic Nanotherapy

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