X-Ray-Responsive Zeolitic Imidazolate Framework-Capped Nanotherapeutics for Cervical Cancer-Targeting Radiosensitization

Shuya Pan; Guanning Huang; Zhengwei SunXin ChenXinli XiangWenxiao JiangYanchao XuTianfeng ChenXueqiong Zhu

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X-Ray-Responsive Zeolitic Imidazolate Framework-Capped Nanotherapeutics for Cervical Cancer-Targeting Radiosensitization

机译：X-Ray-Responsive Zeolitic Imidazolate Framework-Capped Nanotherapeutics for Cervical Cancer-Targeting Radiosensitization

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Developing radiosensitizers based on the characteristics of the tumor microenvironmentcan improve the effectiveness and overcome the bottleneck of cervicalcancer radiotherapy. Herein, an in situ synthesis strategy is demonstratedby using a highly bioactive zeolitic imidazolate framework to cap Mn_3O_4 andfolic acid as targeting molecules (FA-Mn_3O_4@ZIF-8) to achieve enhanced radiosensitizationagainst cervical cancer. As expected, the ZIF-8 cap on the surfaceof Mn_3O_4 responds more effectively to X-rays. Meanwhile, by facilitatingthe presence of oxygen vacancies and valence transition of manganese on thesurface of Mn_3O_4, the ZIF-8 cap on Mn_3O_4 can increase the catalytic capacityfor hydrogen peroxide (H_2O_2) and glutathione as well as produce more singletoxygen under X-ray, alleviate hypoxia within the tumor microenvironment,and increase reactive oxygen species production. Moreover, FA-Mn_3O_4@ZIF-8shows excellent radiotherapy-sensitizing properties in vitro and in vivo bypromoting DNA damage and apoptosis. Collectively, this study suggests thatdesigning and construction of X-ray responsive nanoradiosensitizers could bea good way for future clinical radiotherapy of malignant cervical cancer.

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来源
《Advanced functional materials》 |2023年第13期|2213364.1-2213364.16|共16页
作者
Shuya Pan; Guanning Huang; Zhengwei SunXin ChenXinli XiangWenxiao JiangYanchao XuTianfeng ChenXueqiong Zhu;
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Department of Obstetrics and GynecologyThe Second Affiliated Hospital and Yuying Children’sHospital of Wenzhou Medical UniversityWenzhou 325000, China;

Department of Chemistry, MOE Key Laboratory of Tumor MolecularBiologyJinan UniversityGuangzhou 510632, China;

Department of Obstetrics and GynecologyThe Second Affiliated Hospital and Yuying Children’sHospital of Wenzhou Medical UniversityWenzhou 325000, China, Department of Chemistry, MOE Key Laboratory of Tumor MolecularBiologyJinan UniversityGuangzhou 510632,;

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正文语种英语
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cervical cancers; radiotherapy sensitizers; X-ray-responses; zeolitic imidazolate frameworks;

X-Ray-Responsive Zeolitic Imidazolate Framework-Capped Nanotherapeutics for Cervical Cancer-Targeting Radiosensitization

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