Sewage Protein Information Mining: Discovery of Large Biomolecules as Biomarkers of Population and Industrial Activities

Montserrat Carrascal; Ester Sanchez-Jimenez; Jie Fang

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Sewage Protein Information Mining: Discovery of Large Biomolecules as Biomarkers of Population and Industrial Activities

机译：Sewage Protein Information Mining: Discovery of Large Biomolecules as Biomarkers of Population and Industrial Activities

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Wastewater-based epidemiology has been revealed as a powerful approach for surveying the health and lifestyle of a population. In this context, proteins have been proposed as potential biomarkers that complement the information provided by currently available methods. However, little is known about the range of molecular species and dynamics of proteins in wastewater and the information hidden in these protein profiles is still to be uncovered. In this study, we investigated the protein composition of wastewater from 10 municipalities in Catalonia with diverse populations and industrial activities at three different times of the year. The soluble fraction of this material was analyzed using liquid chromatography high-resolution tandem mass spectrometry using a shotgun proteomics approach. The complete proteomic profile, distribution among different organisms, and semiquantitative analysis of the main constituents are described. Excreta (urine and feces) from humans, and blood and other residues from livestock were identified as the two main protein sources. Our findings provide new insights into the characterization of wastewater proteomics that allow for the proposal of specific bioindicators for wastewater-based environmental monitoring. This includes human and animal population monitoring, most notably for rodent pest control (immunoglobulins (Igs) and amylases) and livestock processing industry monitoring (albumins).

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《Environmental Science & Technology: ES&T》 |2023年第30期|10929-10939|共11页
作者
Montserrat Carrascal; Ester Sanchez-Jimenez; Jie Fang;
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作者单位

Biological and Environmental Proteomics Group, Institute of Biomedical Research of Barcelona, Spanish National Research Council (IIBB-CSIC/ IDIBAPS), E-08036 Barcelona, Spain;

Biological and Environmental Proteomics Group, Institute of Biomedical Research of Barcelona, Spanish National Research Council (IIBB-CSIC/IDIBAPS), E-08036 Barcelona, Spain;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
environmental proteomics; sewage epidemiology; water fingerprinting; mass spectrometry;

Sewage Protein Information Mining: Discovery of Large Biomolecules as Biomarkers of Population and Industrial Activities

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