Can We Arrest the Evolution of Antibiotic Resistance? TheDifferences between the Effects of Silver Nanoparticles and SilverIons

Zhao Huiru; Wang Meiling; Cui YuetingZhang Chengdong

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Can We Arrest the Evolution of Antibiotic Resistance? TheDifferences between the Effects of Silver Nanoparticles and SilverIons

机译：Can We Arrest the Evolution of Antibiotic Resistance? TheDifferences between the Effects of Silver Nanoparticles and SilverIons

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Silver nanoparticles (AgNPs) are effective anti-microbial substances that show promise in combatting multidrugresistance. The potential application and release of AgNPs into theenvironment may neutralize the selective advantage of antibioticresistance. Systemic knowledge regarding the effect of NPs on theevolution of antibiotic resistance is lacking. Our results showedthat bacteria slowly developed adaptive tolerance to ciprofloxacin(CIP) under cyclic CIP and silver ion (Ag+) cotreatment, and noresistance/tolerance was discernible when CIP and AgNP exposurewas alternated. In contrast, rapid CIP resistance was induced undercontinuous selection by treatment with only CIP. To combat theeffects of CIP and Ag+, bacteria developed convergent evolutionarystrategies with similar adaptive mechanisms, including anaerobicrespiration transitioning (to reduce oxidative stress) and stringent response (to survive harsh environments). Alternating AgNPexposure impeded evolutionary resistance by accelerating B12-dependent folate and methionine cycles, which reestablished DNAsynthesis and partially offset high oxidative stress levels, in contrast with the effect of CIP-directed evolutionary pressure.Nevertheless, CIP/AgNP treatment was ineffective in attenuating virulence, and CIP/Ag+exposure even induced the virulence-critical type III secretion system. Our results increase the basic understanding of the impacts of NPs on evolutionary biology andsuggest prospective nanotechnology applications for arresting evolutionary antibiotic resistance.

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来源
《Environmental Science & Technology: ES&T》 |2022年第8期|5090-5101|共12页
作者
Zhao Huiru; Wang Meiling; Cui YuetingZhang Chengdong;
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作者单位

Beijing Normal Univ;

Nankai Univ;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
AgNPs; nbsp; Ag+; evolution; antibiotic resistance; B12; PSEUDOMONAS-AERUGINOSA; III SECRETION; CIPROFLOXACIN RESISTANCE; BACTERIA; VITAMIN-B-12; MECHANISMS; INFECTIONS; PYOVERDINE; BIOFILMS; GROWTH;

Can We Arrest the Evolution of Antibiotic Resistance? TheDifferences between the Effects of Silver Nanoparticles and SilverIons

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