Endocannabinoid‐mediated neuromodulation in the main olfactory bulb at the interface of environmental stimuli and central neural processing

Thomas Heinbockel; Naina Bhatia‐Dey; Vonnie D. C. ShieldsLuigi Bellocchio

首页> 外文期刊>The European journal of neuroscience. >Endocannabinoid‐mediated neuromodulation in the main olfactory bulb at the interface of environmental stimuli and central neural processing

【24h】

Endocannabinoid‐mediated neuromodulation in the main olfactory bulb at the interface of environmental stimuli and central neural processing

机译：Endocannabinoid‐mediated neuromodulation in the main olfactory bulb at the interface of environmental stimuli and central neural processing

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Abstract The olfactory system has become an important functional gateway to understand and analyze neuromodulation since olfactory dysfunction and deficits have emerged as prodromal and, at other times, as first symptoms of many of neurodegenerative, neuropsychiatric and communication disorders. Considering olfactory dysfunction as outcome of altered, damaged and/or inefficient olfactory processing, in the current review, we analyze how olfactory processing interacts with the endocannabinoid signaling system. In the human body, endocannabinoid synthesis is a natural and on‐demand response to a wide range of physiological and environmental stimuli. Our current understanding of the response dynamics of the endocannabinoid system is based in large part on research advances in limbic system areas, such as the hippocampus and the amygdala. Functional interactions of this signaling system with olfactory processing and associated pathways are just emerging but appear to grow rapidly with multidimensional approaches. Recent work analyzing the crystal structure of endocannabinoid receptors bound to their agonists in a signaling complex has opened avenues for developing specific therapeutic drugs that could help with neuroinflammation, neurodegeneration, and alleviation/reduction of pain. We discuss the role of endocannabinoids as signaling molecules in the olfactory system and the relevance of the endocannabinoid system for synaptic plasticity.

著录项

来源
《The European journal of neuroscience.》 |2022年第4期|1002-1014|共13页
作者
Thomas Heinbockel; Naina Bhatia‐Dey; Vonnie D. C. ShieldsLuigi Bellocchio;
展开▼
作者单位

Department of Anatomy,Howard University College of Medicine;

Biological Sciences Department,Towson University;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类神经病学与精神病学;
关键词
Alzheimer's disease; animal model; cannabinoid; cannabis; endocannabinoid; marijuana; olfactory cortex; Parkinson's disease;

Endocannabinoid‐mediated neuromodulation in the main olfactory bulb at the interface of environmental stimuli and central neural processing

摘要

著录项

相关主题

期刊订阅