Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan

Jing Chen; Peisi Xie; Pengfei Wu

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Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan

机译：Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan

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Triclosan(TCS),an antimicrobial compound,is known to have potential endocrine-disruptive properties,but the underlying toxic mechanisms at the metabolic level are not well understood.Here,we applied metabolomics and lipidomics combined with mass spectrometry imaging(MSI)to unveil the mechanisms of the enhanced growth of MCF-7 breast cancer cell spheroids(CCS)exposed to TCS.To obtain a wide coverage of metabolites and lipids by using MSI,we used techniques of matrix-assisted laser desorption/ionization(MALDl)and MALDI coupled with laser-postionization.The results showed that TCS and TCS sulfate penetrated into the entire area at 0-3 h and both localized in the inner area at 6 h.After 24 h,a portion of two compounds was released from CCS.Omic data indicated that TCS exposure induced alterations via several pathways,including energy metabolism and biosynthesis of glycerophospholipids and glycerolipids.Further MSI data revealed that the enhancement of energy supply in the peripheral area and the increase of energy storage in the inner area might contribute to the enhanced growth of MCF-7 breast CCS exposed to TCS.This study highlights the importance of integrating metabolite distributions and metabolic profiles to reveal the novel mechanisms of TCS-triggered endocrine disrupting effects.

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《Environmental Science & Technology: ES&T》 |2023年第29期|10542-10553|共12页
作者
Jing Chen; Peisi Xie; Pengfei Wu;
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作者单位

Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology,Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety,College of Chemistry,Fuzhou University,Fuzhou,Fujian 350116,China;

State Key Laboratory of Environmental and Biological Analysis,Department of Chemistry,Hong Kong Baptist University,Kowloon 999077,Hong Kong SAR,China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
triclosan; breast cancer cell spheroids; enhanced growth; metabolites and lipids; mass spectrometry imaging;

Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan

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