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首页> 外文期刊>AIDS care. >Video directly observed therapy to improve adherence of humanimmunodeficiency virus infected adolescents to combination antiretroviraltherapy: a proof-of-concept study
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Video directly observed therapy to improve adherence of humanimmunodeficiency virus infected adolescents to combination antiretroviraltherapy: a proof-of-concept study

机译：Video directly observed therapy to improve adherence of humanimmunodeficiency virus infected adolescents to combination antiretroviraltherapy: a proof-of-concept study

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摘要

Adherence to antiretroviral therapy (ART) is a major challenge for many youth living with HIV(YLWH). In this prospective proof-of-concept study, we assessed the feasibility and acceptabilityof conducting a study of video directly observed therapy (VDOT) as a method of improvingmedication adherence in YLWH who had a history of poor adherence to ART. The study hadfour phases; phase I - VDOT daily (4 months) using Facetime’; phase II - daily texting (2months); phase III - weekly texting (3 months); phase IV - no intervention (3 months).Participants were seen in clinic on a monthly basis for assessment and laboratory evaluation.Five of eight eligible participants were enrolled. All achieved virologic suppression one monthafter enrollment. Three of five completed the study protocol and maintained virologicsuppression through the 12-month period of study. Participant responses to the end-of-study questionnaire indicated satisfaction with the intervention and thought VDOT was helpfulto them. Healthcare providers thought that the intervention was effective for some youth butwas at times burdensome. This proof-of-concept study demonstrated that VDOT may beeffective at improving medication adherence in previously poorly adherent YLWH and thatlarger studies of VDOT for such patients are both feasible and warranted.

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