Infection Micromilieu-Activated Nanocatalytic Membrane for Orchestrating Rapid Sterilization and Stalled Chronic Wound Regeneration

Zhou Xiong; Wang Ziyou; Chan Yau KeiYang YingmingJiao ZhengLi LimeiLi JiyaoLiang KunnengDeng Yi

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Infection Micromilieu-Activated Nanocatalytic Membrane for Orchestrating Rapid Sterilization and Stalled Chronic Wound Regeneration

机译：Infection Micromilieu-Activated Nanocatalytic Membrane for Orchestrating Rapid Sterilization and Stalled Chronic Wound Regeneration

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Pathogenic infection inevitably provokes chronic inflammation and stalls the normal orchestrated course of wound-healing cascades. However, current antibacterial therapies focus on the inherent bactericidal functions of biomaterials. To take full advantage of infection microenvironment (IME) peculiarities, an IME-activated nanocatalytic membrane consisting of electrospun poly (lactic-co-glycolic acid) (PLGA) scaffolds, MXene/Ag2S bio-heterojunctions (MX/AS bio-HJs), and lactate oxidase (LOx) for chronic cutaneous regeneration is devised and developed. In this "intelligent" system, PLGA membranes gradually degrade to lactate, and LOx consumes lactate to yield abundant hydrogen peroxide (H2O2) in a microenvironment-responsive manner. In addition, MX/AS bio-HJs in membranes not only exert benign photothermal effects and generate reactive oxygen species upon NIR light, but also catalyze the produced H2O2 to overwhelming hydroxyl radicals (center dot OH) through Fenton-like reactions, which all result in rapid synergistic sterilization. Furthermore, in vivo assays demonstrate that the nanocatalytic membranes reshape the stalled chronic wound into a regenerative wound by massacring bacteria, stopping bleeding, boosting epithelialization/collagen deposition of the wound beds, and promoting angiogenesis. As envisaged, the proposed tactic opens up a promising opportunity for arming membranes with IME-responsive nanocatalytic activity to remedy bacteria-invaded stalled full-thickness wounds.

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《Advanced functional materials》 |2022年第7期|2109469.1-2109469.23|共23页
作者
Zhou Xiong; Wang Ziyou; Chan Yau KeiYang YingmingJiao ZhengLi LimeiLi JiyaoLiang KunnengDeng Yi;
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Sichuan Univ, Sch Chem Engn, State Key Lab Oral Dis, West China Coll Stomatol, Chengdu 610065, Peoples R China|City Univ Hong Kong, Dept Biomed Engn, Hong Kong 999077, Peoples R China;

Sichuan Univ, Sch Chem Engn, State Key Lab Oral Dis, West China Coll Stomatol, Chengdu 610065, Peoples R China|Sichuan Univ, West China Hosp Stomatol, Dept Cariol & Endodont, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Peoples R China;

Univ Hong Kong, Dept Ophthalmol, Hong Kong 999077, Peoples R ChinaSichuan Univ, Pittsburgh Inst, Chengdu 610207, Peoples R ChinaKunming Med Univ, Sci & Technol Achievement Incubat Ctr, Kunming 650500, Yunnan, Peoples R ChinaSichuan Univ, Sch Chem Engn, State Key Lab Oral Dis, West China Coll Stomatol, Chengdu 610065, Peoples R China|Sichuan Univ, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China|Univ Hong Kong, Dept Mech Engn, Hong Kong 999077, Peoples R China;

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antibacterial; bio-heterojunction; membrane; MXene; tissue regeneration;

Infection Micromilieu-Activated Nanocatalytic Membrane for Orchestrating Rapid Sterilization and Stalled Chronic Wound Regeneration

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