A Multifunctional Hybrid Graphene and Microfluidic Platform to Interface Topological Neuron Networks

Victor Dupuit; Oceane Terral; Guillaume BresArnaud ClaudelBruno FernandezAnne Briancon-MarjolletCecile Delacour

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A Multifunctional Hybrid Graphene and Microfluidic Platform to Interface Topological Neuron Networks

机译：A Multifunctional Hybrid Graphene and Microfluidic Platform to Interface Topological Neuron Networks

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The nervous system is as complex as difficult to probe. Innovative toolsreducing the network complexity and being able to interrogate neurons arecrucial to better understand its function and organization. In this study,solution-gated graphene field effect transistors (GFETs) are combined withmulti-compartment microfluidic platform for multimodal and long-lastingrecording of neuron electrical activity. The fluidic microchannels, somatic andsynaptic chambers enable to define the neuron network topology, while thegraphene devices provide localized, highly sensitive, and optically transparentsensing sites. Immunofluorescence staining assesses for the healthy state andoutgrowth of neurons within the microfluidic circuit, while calcium imagingdemonstrates the maturation and spontaneous activity of the designednetwork. The efficient cell-sensor alignment obtained by the microfluidiccircuit enables to reach the highest reported signal-to-noise ratio for singleunitsdetection with GFETs, revealing additional information that can remainhidden from recordings when using conventional microelectrode arrays. Thus,the combination of graphene sensors and microfluidic circuits leverages theadvantages of two state-of-the-art technologies for highly efficient sensing ofmodel neural networks. Being fully transparent and therefore compatible withoptogenetic tools and high-resolution microscopy, this novel platform canprovide a versatile lab-on-chip for diagnosis and treatment of tomorrow.

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来源
《Advanced functional materials》 |2022年第49期|2207001.1-2207001.14|共14页
作者
Victor Dupuit; Oceane Terral; Guillaume BresArnaud ClaudelBruno FernandezAnne Briancon-MarjolletCecile Delacour;
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作者单位

Institut NeelGrenoble Alpes UniversityCNRSGrenoble INP38000 Grenoble, France;

HP2 LaboratoryInstitut National de la Sante et de la Recherche Medicale U1300Grenoble Alpes University38000 Grenoble, France;

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正文语种英语
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field effect transistors; graphene; lab-on-chips; microelectrodes; microfluidic; nanoelectronics; neuron networks;

A Multifunctional Hybrid Graphene and Microfluidic Platform to Interface Topological Neuron Networks

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