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>In‐vivo and in‐vitro studies on DDT uptake and metabolism in susceptible and resistant strains of the mosquitoAedes aegyptiL.
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In‐vivo and in‐vitro studies on DDT uptake and metabolism in susceptible and resistant strains of the mosquitoAedes aegyptiL.
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机译：In‐vivo and in‐vitro studies on DDT uptake and metabolism in susceptible and resistant strains of the mosquitoAedes aegyptiL.
AbstractTwelve strains ofAedes aegyptihave been compared for resistance topp′‐DDT, uptake ofpp′‐DDT, and dehydrochlorination ofpp′‐DDT topp′‐DDEin vivoandin vitroboth at the larval and adult stages. Resistant larvae were shown to contain significantly morepp′‐DDE than susceptible larvae after a standard exposure topp′‐DDT but also substantially morepp′‐DDT in an unmetabolised state. There was a small increase in the percentage dehydrochlorinatedin vivoin the resistant strains compared with the susceptible strains, but this was not correlated with the level of resistance nor with dehydrochlorinationin vitro.However, dehydrochlorinationin vitrowas correlated with resistance. Adult resistance was correlated positively with dehydrochlorination, bothin vivoandin vitro, but the resistant adults did not contain increased levels of unmetabolised DDT. By comparing resistance levels at the two stages, it was found that there were two kinds of resistant strain: four strains of Asian origin and one from West Africa were highly resistant as larvae but showed almost no resistance as adults; five strains from Central and South America were highly resistant at both stages. The different mechanisms of resistance in adults and larvae are discussed in
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