A Novel Hollow-Tube-Biphasic-Whisker-Modified Calcium Phosphate Ceramics with Simultaneously Enhanced Mechanical Strength and Osteogenic Activity

Cong Feng; Yonghao Wu; Qipeng LiTinghan HeQuanle CaoXiangfeng LiYumei XiaoJiangli LinXiangdong ZhuXingdong Zhang

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A Novel Hollow-Tube-Biphasic-Whisker-Modified Calcium Phosphate Ceramics with Simultaneously Enhanced Mechanical Strength and Osteogenic Activity

机译：A Novel Hollow-Tube-Biphasic-Whisker-Modified Calcium Phosphate Ceramics with Simultaneously Enhanced Mechanical Strength and Osteogenic Activity

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Due to the inherent brittleness and low mechanical strength, it is still a challenge for calcium phosphate (Ca-P) ceramics to be used in load-bearing bone defect repair. To achieve a good balance between mechanical strength and osteogenic activity, hollow-tube-whisker-modified biphasic calcium phosphate (BCP) ceramics (BCP-HW) are successfully fabricated by an in situ growth process in the present study. Compared to the initial BCP ceramics (BCP-C) and those with solid whiskers, BCP-HW exhibits larger specific surface area (3.9 times vs BCP-C) and higher mechanical strength (3.4 times vs BCP-C), endowing it with stronger stimulation on adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells. In an intramuscular implantation model of canine, BCP-HW shows excellent osteoinductivity and promotes the maturation of new bone, and the resultant compressive strength of the implant increases to ≈12 MPa at 3 months postoperatively. In another critical-sized segmental bone defect model of rabbit femur, BCP-HW has the best repairing effect. After implantation for 6 months, much more new bone ingrowth and higher bending load are observed in BCP-HW than BCP-C. Collectively, these findings suggest that the in situ hollow-tube whisker construction possesses immense potential in expanding the applications of Ca-P ceramics to load-bearing bone defect repair.

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来源
《Advanced functional materials》 |2022年第44期|2204974.1-2204974.16|共16页
作者
Cong Feng; Yonghao Wu; Qipeng LiTinghan HeQuanle CaoXiangfeng LiYumei XiaoJiangli LinXiangdong ZhuXingdong Zhang;
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作者单位

National Engineering Research Center for Biomaterials College of Biomedical Engineering Sichuan University Chengdu 610064, China;

School of Chemical Engineering Sichuan University Chengdu 610064, China;

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正文语种英语
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Ca-P ceramics; hollow-tube whiskers; mechanical strength; osteoinductivity; segmental bone defects;

A Novel Hollow-Tube-Biphasic-Whisker-Modified Calcium Phosphate Ceramics with Simultaneously Enhanced Mechanical Strength and Osteogenic Activity

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