GEVI cell-type specific labelling and a manifold learning approach provide evidence for lateral inhibition at the population level in the mouse hippocampal CA1 area

Ryuichi Nakajima; Nikolaos Laskaris; Jun Kyu RheeBradley J. BakerEfstratios K. Kosmidis

首页> 外文期刊>The European journal of neuroscience. >GEVI cell-type specific labelling and a manifold learning approach provide evidence for lateral inhibition at the population level in the mouse hippocampal CA1 area

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GEVI cell-type specific labelling and a manifold learning approach provide evidence for lateral inhibition at the population level in the mouse hippocampal CA1 area

机译：GEVI cell-type specific labelling and a manifold learning approach provide evidence for lateral inhibition at the population level in the mouse hippocampal CA1 area

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The CA1 area in the mammalian hippocampus is essential for spatial learning. Pyramidal cells are the hippocampus output neurons and their activities are regulated by inhibition exerted by a diversified population of interneurons. Lateral inhibition has been suggested as the mechanism enabling the reconfiguration of pyramidal cell assembly activity observed during spatial learning tasks in rodents. However, lateral inhibition in the CA1 lacks the overwhelming evidence reported in other hippocampal areas such as the CA3 and the dentate gyrus. The use of genetically encoded voltage indicators and fast optical recordings permits the construction of cell-type specific response maps of neuronal activity. Here, we labelled mouse CA1 pyramidal neurons with the genetically encoded voltage indicator ArcLight and optically recorded their response to Schaffer Collaterals stimulation in vitro. By undertaking a manifold learning approach, we report a hyperpolarization-dominated area focused in the perisomatic region of pyramidal cells receiving late excitatory synaptic input. Functional network organization metrics revealed that information transfer was higher in this area. The localized hyperpolarization disappeared when GABA_A receptors were pharmacologically blocked. This is the first report where the spatiotem-poral pattern of lateral inhibition is visualized in the CA1 by expressing a genetically encoded voltage indicator selectively in principal neurons. Our analysis suggests a fundamental role of lateral inhibition in CA1 information processing.

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《The European journal of neuroscience.》 |2021年第9期|3019-3038|共20页
作者
Ryuichi Nakajima; Nikolaos Laskaris; Jun Kyu RheeBradley J. BakerEfstratios K. Kosmidis;
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作者单位

Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea;

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正文语种英语
中图分类神经病学与精神病学;
关键词
ArcLight; CA1; functional network organization; genetically encoded voltage indicators; lateral inhibition; manifold learning; optical recordings;

GEVI cell-type specific labelling and a manifold learning approach provide evidence for lateral inhibition at the population level in the mouse hippocampal CA1 area

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