• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced functional materials >Injectable Reactive Oxygen Species-Responsive Hydrogel Dressing with Sustained Nitric Oxide Release for Bacterial Ablation and Wound Healing
【24h】

Injectable Reactive Oxygen Species-Responsive Hydrogel Dressing with Sustained Nitric Oxide Release for Bacterial Ablation and Wound Healing

机译：Injectable Reactive Oxygen Species-Responsive Hydrogel Dressing with Sustained Nitric Oxide Release for Bacterial Ablation and Wound Healing

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Skin wound healing strategies that promote sustainable healing, preventbacterial infections, and cause only mild irritation are urgently needed foropen wound therapy. In this study, a system that consists of a reactive oxygenspecies (ROS)-degradable hydrogel dressing, with encapsulated biosafe nitricoxide (NO) donor L-arginine (L-Arg), and a low level (100 × 10~(?6) m) of thehousehold disinfectant hydrogen peroxide (H_2O_2) is established for sustainablewound therapy and disinfection. Under stimulation with a low level ofH_2O_2, NO is sustainably generated from L-Arg within the hydrogel dressing,which mediates macrophage and fibroblast chemotaxis to the wound site,as well as collagen synthesis, resulting in rapid wound healing and skinorgan regeneration. The combination of H_2O_2 and NO also endows thesystem with a synergistic antibacterial ability to eliminate ampicillin-resistantEscherichia coli. In addition, a full-thickness skin wound model demonstratesthat the ROS-degradable hydrogel dressing, with a wound exudate adsorptionability, shows effective wound healing promotion and a good biocompatibility,without any hazardous residues and skin irritation. This ROS-responsive,degradable, synergistic wound healing system provides an alternativestrategy for sustainable wound treatment, both at home and in the clinic.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号