Neuro-protective potentials of N-acetylcysteine and zinc against di(2-ethylhexyl)-phthalate-induced neuro-histopathoiogy and dys-regulations of Dopamine and Glutamate in rat brain

Adelaja Akinlolu; Victor Emojevwe; Raphael UwejighoJuliet llesanmiRokibat OwolabiAbimbola lgandan

首页> 外文期刊>Journal of environmental science and health, Part A. Toxic/hazardous substances & environmental engineering >Neuro-protective potentials of N-acetylcysteine and zinc against di(2-ethylhexyl)-phthalate-induced neuro-histopathoiogy and dys-regulations of Dopamine and Glutamate in rat brain

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Neuro-protective potentials of N-acetylcysteine and zinc against di(2-ethylhexyl)-phthalate-induced neuro-histopathoiogy and dys-regulations of Dopamine and Glutamate in rat brain

机译：Neuro-protective potentials of N-acetylcysteine and zinc against di(2-ethylhexyl)-phthalate-induced neuro-histopathoiogy and dys-regulations of Dopamine and Glutamate in rat brain

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This study examined neuro-protective potentials of N-acetyl-cysteine (NAC) and Zinc on expression levels of Dopamine and Glutamate in the Cerebrum, Hypothalami and Pituitary Glands in Di(2-ethylhexyl)-phthalate (DEHP)-induced neurotoxicity in rats. Thirty-six adult male Wistar rats were randomly divided into 6 groups (n = 6). Group 1 was control. Groups 2-6 received oral administrations of 100 mg/kg NAC, 0.5 mg/kg Zinc, 750 mg/kg DEHP, DEHP+ NAC doses and DEHP + Zinc doses respectively for 21 days. Brain histology (Heamatoxyline and Eosine technique), histochemical and enzyme-linked-immunosorbent assays of Dopamine and Glutamate in homogenates of Cerebrum, Hypothalami and Pituitary Glands were evaluated. Data were statistically analyzed using One-way-ANOVA with Tukey-post-hoc test at p ≤0.05. Histo-pathological evaluations of Cerebrum, Hypothalami and Pituitary Glands showed gross histo-alterations and neurodegenerative changes (Group 4), mild histo- and neuro-degenerative changes (Groups 5 and 6) and normal histology (Group 1). Histochemical analyses showed higher Dopamine levels in Hypothalami (Group 5) and Pituitary Glands (Groups 5 and 6), compared with Group 4. Furthermore, results showed lower Glutamate levels in Cerebrum, Hypothalami and Pituitary Glands of Groups 5 and 6, compared with Group 4. Overall, NAC and Zinc conferred neuro-protection and histo-protection against DEHP-induced neuro-toxicity, neuro-histopathology, decreased Dopamine levels and increased Glutamate levels.

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《Journal of environmental science and health, Part A. Toxic/hazardous substances & environmental engineering》 |2023年第2期|81-90|共10页
作者
Adelaja Akinlolu; Victor Emojevwe; Raphael UwejighoJuliet llesanmiRokibat OwolabiAbimbola lgandan;
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作者单位

Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences Ondo, Ondo City, Ondo State, Nigeria;

Department of Physiology, Faculty of Basic Medical Sciences, University of Medical Sciences Ondo, Ondo City, Ondo State, Nigeria;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
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Neuro-protection; n-acetyl cysteine; zinc; di(2-ethylhexyl) phthalate; neuro-histopathology; dys-regulations;

Neuro-protective potentials of N-acetylcysteine and zinc against di(2-ethylhexyl)-phthalate-induced neuro-histopathoiogy and dys-regulations of Dopamine and Glutamate in rat brain

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