Comparative study of calcification in human choroid plexus, pineal gland, and habenula

O.Junemann; A. G.Ivanova; I.BukreevaD. A.ZolotovM.FratiniA.CedolaF.WildeI. G.DyachkovaYu. S.KrivonosovD. A.OtlygaS. V.Saveliev

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Comparative study of calcification in human choroid plexus, pineal gland, and habenula

机译：Comparative study of calcification in human choroid plexus, pineal gland, and habenula

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Abstract Choroid plexus, pineal gland, and habenula tend to accumulate physiologic calcifications (concrements) over a lifetime. However, until now the composition and causes of the intracranial calcifications remain unclear. The detailed analysis of concrements has been done by us using X-ray diffraction analysis (XRD), X-ray diffraction topography (XRDT), micro-CT, X-ray phase-contrast tomography (XPCT), as well as histology and immunohistochemistry (IHC). By combining physical (XRD) and biochemical (IHC) methods, we identified inorganic (hydroxyapatite) and organic (vimentin) components of the concrements. Via XPCT, XRDT, histological, and IHC methods, we assessed the structure of concrements within their appropriate tissue environment in both two and three dimensions. The study found that hydroxyapatite was a major component of all calcified depositions. It should be noted, however, that the concrements displayed distinctive characteristics corresponding to each specific structure of the brain. As a result, our study provides a basis for assessing the pathological and physiological changes that occur in brain structure containing calcifications.

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《Cell and Tissue Research》 |2023年第3期|537-545|共9页
作者
O.Junemann; A. G.Ivanova; I.BukreevaD. A.ZolotovM.FratiniA.CedolaF.WildeI. G.DyachkovaYu. S.KrivonosovD. A.OtlygaS. V.Saveliev;
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作者单位

Institute of Nanotechnology—CNR (Rome unit), c/o Department of Physics, La Sapienza University;

Federal Scientific Research Centre “Crystallography and Photonics”,Russian Academy of Sciences;

Institute of Materials PhysicsAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution;

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正文语种英语
中图分类细胞生物学;
关键词
Choroid plexus; Pineal gland; Habenula; Immunohistochemistry; X-ray diffraction analysis; X-ray phase contrast tomography;

Comparative study of calcification in human choroid plexus, pineal gland, and habenula

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