Regulation of Synovial Macrophages Polarization by Mimicking Efferocytosis for Therapy of Osteoarthritis

Hongbin Yang; Zhenyan Yu; Shuaishuai JiJie YanYan kongQiang HuoZhijun ZhangYimin NiuYang Liu

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Regulation of Synovial Macrophages Polarization by Mimicking Efferocytosis for Therapy of Osteoarthritis

机译：Regulation of Synovial Macrophages Polarization by Mimicking Efferocytosis for Therapy of Osteoarthritis

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The progression of osteoarthritis is associated with chronic synovitiscaused by synovial macrophage infiltration and proinflammatory M1polarization. Accordingly, repolarization of macrophages from the M1 toM2 phenotype by nanoagents is proposed as a potential treatment strategy.However, achieving adequate effects using intra-articular injected agentsis challenging due to the rapid drug clearance from the joint space andpoor efficiency of nanoparticles endocytosis by synovial macrophage cells.Herein, apoptotic chondrocyte membrane-coated, quercetin-loaded metalorganicframework nanoparticles as immunomodulators for treating osteoarthritisare reported. The apoptotic chondrocyte membrane-camouflagednanoparticles containing various natural “eat me” signals can be easilydisguised as chondrocyte apoptotic bodies in the joints, and thus are moreeasily phagocytized by synovial macrophages similarly to efferocytosis.Furthermore, the released quercetin promotes the polarization of synovialmacrophagesto the M2 phenotype and also inhibites the apoptosis ofarticular chondrocytes. In vivo results suggest that such a “Trojan horse”strategy can extend the retention time of nanoparticles in osteoarthritisjoints and improve treatment efficacy. Collectively, it is hoped that this studycan offer a potential and universal platform for engineered cell membranecoatednanoparticles to resolve inflammation by simulating specific inflammatoryprocesses.

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《Advanced functional materials》 |2022年第51期|2207637.1-2207637.14|共14页
作者
Hongbin Yang; Zhenyan Yu; Shuaishuai JiJie YanYan kongQiang HuoZhijun ZhangYimin NiuYang Liu;
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作者单位

Department of NeurologyAffliated Zhongda HospitalSchool of MedicineInstitution of NeuropsychiatrySoutheast UniversityNanjing, Jiangsu 210009, China;

Department of PharmaceuticsSchool of PharmacyNanjing Medical UniversityNanjing, Jiangsu 211166, China;

Depar;

Key Laboratory of Cardiovascular and Cerebrovascular MedicineSchool of PharmacyNanjing Medical UniversityNanjing, Jiangsu 211166, China;

School of PharmacyBengbu Medical CollegeBengbu, Anhui 233030, ChinaDepartment of NeurologyAffliated Zhongda HospitalSchool of MedicineInstitution of NeuropsychiatrySoutheast UniversityNanjing, Jiangsu 210009, China;

Department of Mental Health and Public HealthFaculty of Life and Health SciencesShenzhen Institute of AdvanDepartment of NeurologyAffliated Zhongda HospitalSchool of MedicineInstitution of NeuropsychiatrySoutheast UniversityNanjing, Jiangsu 210009, China;

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正文语种英语
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apoptotic bodies; biomimetic nanoparticles; efferocytosis; osteoarthritis; synovial macrophages;

Regulation of Synovial Macrophages Polarization by Mimicking Efferocytosis for Therapy of Osteoarthritis

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