An Injectable Rapid-Adhesion and Anti-Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing

Shaoquan Bian; Liuzhi Hao; Xin QiuJun WuHao ChangGuan-Ming KuangSheng ZhangXiaohua HuYakang DaiZhiyong ZhouFangli HuangChun LiuXuenong ZouWenguang LiuWillima W. LuHaobo PanXiaoli Zhao

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An Injectable Rapid-Adhesion and Anti-Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing

机译：An Injectable Rapid-Adhesion and Anti-Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing

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摘要

Injectable hydrogel adhesives integrating both rapid adhesion to wettissues and anti-swelling in humid environments are highly desired for fasthemostasis and wound sealing in surgical applications. Herein, utilizing thesynergistic effect of thermo-sensitive shrinkable nano-micelle gelators andsmall molecular adhesive moieties, an injectable hydrogel with rapid-adhesionand anti-swelling properties (RAAS hydrogel) is fabricated. The RAAShydrogel can undergo ultrafast gelation to achieve wet adhesion within 2 s ofultraviolet illumination and exhibit an outstanding anti-swelling performancewith non-expansion of volume during the whole degradation process. It alsopresents good biocompatibility and low risk of hemolysis. Its fast hemostasisis demonstrated in diverse hemorrhage models with injuries in the liver,artery, heart, cranial vessel, and brain cortex in small animals. Importantly,its volume stability in humid internal environment can maintain the strongadhesion strength and avoid compression injury to spinal cord when appliedfor dura sealing. These data suggest that the injectable RAAS hydrogel holdspotential for the applications of fast hemostasis and wound sealing with thebenefits of stable adhesion and reducing the risk of tissue compression injury.

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来源
《Advanced functional materials》 |2022年第46期|2207741.1-2207741.15|共15页
作者
Shaoquan Bian; Liuzhi Hao; Xin QiuJun WuHao ChangGuan-Ming KuangSheng ZhangXiaohua HuYakang DaiZhiyong ZhouFangli HuangChun LiuXuenong ZouWenguang LiuWillima W. LuHaobo PanXiaoli Zhao;
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Guangdong Provincial Key Laboratory of Orthopaedics andTraumatologyDepartment of Spine SurgeryInstitute of Orthopaedic ResearchThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080, China;

School of Material Science and EngineeringTianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin 300072, China;

Department of Orthopaedics and TraumatologyLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077, ChinaResearch Center for Human Tissue and Organs DegenerationInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055, ChinaResearch Center for Human Tissue and Organs DegenerationInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055, China;

University of Chinese Academy of SciencesBeijing 100049, ChinaShenzhen Key Laboratory for Innovative Technology in OrthopaedicTraumaDepartment of Orthopaedics and TraumatologyThe University of Hong Kong-Shenzhen HospitalShenzhen 518048, ChinaDepartment of orthopedicsNanfang Hospital Affiliate to Southern Medical UniversityGuangzhou 510515, ChinaDepartment of Burns and Plastic SurgeryBeijing Jishuitan HospitalBeijing 100035, ChinaSuzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163, China;

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正文语种英语
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adhesive hydrogels; anti-swelling; compression injuries; hemostasis; wound sealing;

An Injectable Rapid-Adhesion and Anti-Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing

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