Researchers at the Indiana University School of Optometry (Bloomington, IN, USA; https://optometry.iu.edu/) developed a multimodal imaging system combining structural and functional imaging to enable 3D visual evaluation of cell-level activities involved in developmental or disease conditions of the eyes. Specifically, the researchers used high-resolution optical coherence microscopy(HR-OCM), a 3D structural technique, and dual-channel scanning confocal fluorescence microscopy (DC-SCFM), a functional technique, to simultaneously register imaging information. The researchers say the combined system could lead to imaging processes that allow biologists to evaluate changes in cellular activity in the eyes of small animals over time. For example, scientists could tag and then follow a specific protein within a cell using the functional system and the area around the cell, such as neighboring cells, with the structural system.
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