HAp Thermosensitive Nanohydrogel Cavities Act as Brood Pouches to Incubate and Control-Release NSCs for Rapid Spinal Cord Injury Therapy

Min Hao; Dapeng Zhang; Wenhan WangZhijian WeiJiazhi DuanJianlong HeXiaohong KongYuanhua SangShiqing FengHong Liu

首页> 外文期刊>Advanced functional materials >HAp Thermosensitive Nanohydrogel Cavities Act as Brood Pouches to Incubate and Control-Release NSCs for Rapid Spinal Cord Injury Therapy

【24h】

HAp Thermosensitive Nanohydrogel Cavities Act as Brood Pouches to Incubate and Control-Release NSCs for Rapid Spinal Cord Injury Therapy

机译：HAp Thermosensitive Nanohydrogel Cavities Act as Brood Pouches to Incubate and Control-Release NSCs for Rapid Spinal Cord Injury Therapy

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Limitations such as the cell life span, cellular activity, and cellular diffusionoutside the lesion make the direct repair of spinal cord injury (SCI) by neuralstem cell (NSC) transplantation challenging. Here, an injectable hydroxyapatite(HAp) thermosensitive nanohydrogel is proposed to achieve stem cellstorage and release, as well as fate regulation, for therapy. The cavitiesformed in situ functioned as brood pouches for cell proliferation. The enzymeinducedcollapse of cavities released mouse NSCs (mNSCs) gradually andcontinuously. The endocytosis of HAp nanorods by encapsulated mNSCsenhanced the property of mNSC neuronal differentiation. The HAp thermosensitivenanohydrogel with mNSCs exert an inspiring therapeutic effect ona complete transected SCI model and has prospects in material design toimprove SCI therapy with stem cells.

著录项

来源
《Advanced functional materials》 |2022年第31期|2203492.1-2203492.15|共15页
作者
Min Hao; Dapeng Zhang; Wenhan WangZhijian WeiJiazhi DuanJianlong HeXiaohong KongYuanhua SangShiqing FengHong Liu;
展开▼
作者单位

State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100, China;

Department of OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012, China;

Department of OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012, China,Tianjin Key Laboratory of Spine and Spinal Cord InjuryTianjin Medical University General HospitalTianjin 300052, ChinaState Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100, China,Department of OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012, China,Tianjin Key Laboratory of Spine and Spinal Cord InjuryTianjin Medical UState Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100, China,Institute for Advanced Interdisciplinary Research (IAIR)University of JinanJinan 250022, China;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
hydroxyapatite thermosensitive nanohydrogels; neural differentiation; release; spinal cord injury repair; stem cells; storage;

HAp Thermosensitive Nanohydrogel Cavities Act as Brood Pouches to Incubate and Control-Release NSCs for Rapid Spinal Cord Injury Therapy

摘要

著录项

相关主题

期刊订阅