Drug-Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia-Reperfusion Therapy in Stroke

Wenxiu He; Xiao-Yong Zhang; Xiang GongKuankuan LuoXuening MaoEnhao LuYiting ChenRui WangZhiwen ZhangJing ZhaoXianyi Sha

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Drug-Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia-Reperfusion Therapy in Stroke

机译：Drug-Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia-Reperfusion Therapy in Stroke

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Recanalization intervention is the primary recommended therapy for ischemic stroke, but the rapid progression of brain damage results in a very narrow time window for ischemia-reperfusion therapy, which remains the biggest obstacle for ischemic stroke treatment. Herein, a drug-free biomimetic nanovehicle capable of improving cerebral ischemic tolerance and thus promoting ischemia-reperfusion therapy is reported. The nanovehicle comprises an amphiphilic polyfluorocarbon, which delivers oxygen to alleviate the hostile hypoxic environment of ischemic brain, and Pluronic P123, which inhibits matrix metalloproteinase-9 to protect the blood–brain barrier (BBB). When intravenously injected into ischemic stroke rats with transient middle cerebral artery occlusion, these nanovehicles are able to preferentially access cerebral ischemic lesions in an inflammation-directed manner, conferring robust ischemic tolerance and reperfusion resistance of brain tissues for ischemia-reperfusion therapy. Furthermore, it is also demonstrated that the nanovehicle is beneficial for mice with permanent ischemic stroke induced by photothrombosis. This work suggests a promising strategy with hypoxia relief and BBB protection for ischemic stroke therapy.

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《Advanced functional materials》 |2023年第21期|2212919.1-2212919.15|共15页
作者
Wenxiu He; Xiao-Yong Zhang; Xiang GongKuankuan LuoXuening MaoEnhao LuYiting ChenRui WangZhiwen ZhangJing ZhaoXianyi Sha;
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作者单位

Key Laboratory of Smart Drug Delivery (Ministry of Education) Minhang Hospital Institutes of Integrative Medicine Department of Pharmaceutics School of Pharmacy Fudan University Shanghai 201203, China,NMPA Key Laboratory for Technology Research and Evalua;

Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University) Ministry of Education Shanghai 200433, China;

State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203, ChinaKey Laboratory of Smart Drug Delivery (Ministry of Education) Minhang Hospital Institutes of Integrative Medicine Department of Pharmaceutics School of Pharmacy Fudan University Shanghai 201203, ChinaDepartment of Neurology Minhang Hospital Fudan University Shanghai 201102, China;

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正文语种英语
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BBB protection; drug-free biomimetic nanovehicles; hypoxia relief; ischemia-reperfusion therapy; ischemic strokes;

Drug-Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia-Reperfusion Therapy in Stroke

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