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首页> 外文期刊>Advanced functional materials >A Synthetic Dynamic Polyvinyl Alcohol Photoresin for Fast Volumetric Bioprinting of Functional Ultrasoft Hydrogel Constructs
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A Synthetic Dynamic Polyvinyl Alcohol Photoresin for Fast Volumetric Bioprinting of Functional Ultrasoft Hydrogel Constructs

机译：A Synthetic Dynamic Polyvinyl Alcohol Photoresin for Fast Volumetric Bioprinting of Functional Ultrasoft Hydrogel Constructs

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摘要

Tomographic volumetric bioprinting (VBP) enables fast photofabricationof cell-laden hydrogel constructs in one step, addressing the limitationsof conventional layer-by-layer additive manufacturing. However, existingbiomaterials that fulfill the physicochemical requirements of VBP are limitedto gelatin-based photoresins of high polymer concentrations. The printedmicroenvironments are predominantly static and stiff, lacking sufficientcapacity to support 3D cell growth. Here a dynamic resin based on thiol–enephoto-clickable polyvinyl alcohol (PVA) and thermo-sensitive sacrificial gelatinfor fast VBP of functional ultrasoft cell-laden hydrogel constructs within7–15 s is reported. Using gelatin allows VBP of permissive hydrogels with lowPVA contents of 1.5%, providing a stress-relaxing environment for fast cellspreading, 3D osteogenic differentiation of embedded human mesenchymalstem cells and matrix mineralization. Additionally, site-specific immobilizationof molecules-of-interest inside a PVA hydrogel is achieved by 3D tomographicthiol–ene photopatterning. This technique may enable spatiotemporal controlof cell-material interactions and guides in vitro tissue formation usingprogrammed cell-friendly light. Altogether, this study introduces a syntheticdynamic photoresin enabling fast VBP of functional ultrasoft hydrogel constructswith well-defined physicochemical properties and high efficiency.

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