Low Levels of Perfluorooctanoic Acid Exposure Activates SteroidHormone Biosynthesis through Repressing Histone Methylation in Rats

Han Xuejingping; Alam Md Nur; Cao MeiyiWang XiaojuanCen MeifengTian MeipingLu YanyangHuang Qingyu

首页> 外文期刊>Environmental Science & Technology: ES&T >Low Levels of Perfluorooctanoic Acid Exposure Activates SteroidHormone Biosynthesis through Repressing Histone Methylation in Rats

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Low Levels of Perfluorooctanoic Acid Exposure Activates SteroidHormone Biosynthesis through Repressing Histone Methylation in Rats

机译：Low Levels of Perfluorooctanoic Acid Exposure Activates SteroidHormone Biosynthesis through Repressing Histone Methylation in Rats

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Perfluorooctanoic acid (PFOA) is a persistentorganic pollutant, which has endocrine-disrupting properties andcan interfere with the synthesis and secretion of testicular steroidhormones, but the underlying molecular mechanisms are still notfully understood. In this study, we investigated the effects of lowdoses of PFOA exposure on testicular steroidogenesis in rats andrevealed the role of histone modifications. It was found that theserum levels of progesterone, testosterone, and estradiol weresignificantly increased after 0.015 and 0.15 mg/kg of PFOAexposure, and the expression ofStar, a key rate-limiting gene, wasup-regulated, while other steroidogenic genesCyp11a1,Hsd3b,Cyp17a1, andHsd17bwere down-regulated. In addition, the levelsof multiple histone modifications (H3K9me1/2/3 and H3K9/18/23ac) were all significantly reduced by PFOA in rat testis. Histone H3K9 methylation is associated with gene silencing, while histoneacetylation leads to gene activation. ChIP analysis further showed that H3K9me1/3 was significantly decreased in the promoterregion ofStar, while H3K18ac levels were down-regulated in other gene promoters. Accordingly, we suggest that low-level PFOAenhances StAR expression through the repression of H3K9me1/3, which stimulates steroid hormone production in rat testis. Theseresults are expected to shed new light on the molecular mechanisms by which low-dose PFOA disturbs male reproductive endocrinefrom an epigenetic aspect and may be useful for human health risk assessment regarding environmental PFOA exposure.

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《Environmental Science & Technology: ES&T》 |2022年第9期|5664-5672|共9页
作者
Han Xuejingping; Alam Md Nur; Cao MeiyiWang XiaojuanCen MeifengTian MeipingLu YanyangHuang Qingyu;
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作者单位

Chinese Acad Sci;

Univ Chinese Acad Sci;

Sun Yat Sen Univ;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
perfluorooctanoic acid; low-dose exposure; histone modification; steroid hormone synthesis; toxicological mechanism; DNA METHYLATION; SUBSTANCES; MECHANISMS; TOXICITY; REVEALS; CELLS;

Low Levels of Perfluorooctanoic Acid Exposure Activates SteroidHormone Biosynthesis through Repressing Histone Methylation in Rats

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