Background: Dementia is an overall term of brain diseases, including Alzheimer’s disease(AD), tauopathies and synucleinopathies. To date, somatic mutations in dementia-related genes, includingthe amyloid precursor protein (APP) gene, presenilin 1 (PSEN1) gene, PSEN2 gene, microtubule-associated protein tau (MAPT) gene, alpha-synuclein (SNCA) gene and leucine-rich repeat kinase2 (LRRK2) gene, have been considered one cause of dementia. We have questioned the impact of somaticmutations in dementia-related genes on cancer.Methods: In the present study, we investigated somatic mutations in the APP, PSEN1, PSEN2, MAPT,SNCA and LRRK2 genes and the impact of these somatic mutations.Results: From The Cancer Genome Atlas (TCGA) database, we found 1,643 somatic mutations in theAPP, PSEN1, PSEN2, MAPT, SNCA and LRRK2 genes in cancer patients. Strikingly, compared to thedistributions of cancer types in total cancer patients, somatic mutations in the dementia-related genesshowed an extremely low distribution in glioblastoma patients.Conclusion: To the best of our knowledge, this is the first investigation of dementia-related genes incancer patients.
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