Association Between Oxidative Stress and Altered Cholesterol Metabolism in Alzheimer’s Disease Patients  Bentham Science

Amira Zarrouk; Souha Hammouda; Imen GhzaielSonia HammamiWided KhamlaouiSamia H. AhmedGérard LizardMohamed Hammami

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Association Between Oxidative Stress and Altered Cholesterol Metabolism in Alzheimer’s Disease Patients Bentham Science

机译：Association Between Oxidative Stress and Altered Cholesterol Metabolism in Alzheimer’s Disease Patients Bentham Science

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Background: Oxidative stress is the main feature of several diseases including Alzheimer’sdisease (AD). The involvement of oxysterols derivates has been recently reported.Objective: The aim of this study was to evaluate the implication of oxidative stress in cholesterolimpairment in AD patients.Methods: A case-control study was conducted on 56 AD patients and 97 controls. Levels of oxidativebiomarkers, including lipid peroxidation products and antioxidant enzyme activities were measured withspectrophotometric methods on red blood cells (RBCs) and plasma. Cholesterol precursors and oxysterols(7-Ketocholeterol (7KC), 7α-hydroxycholesterol (7α-OHC), 7β-hydroxycholesterol (7β-OHC), 24Shydroxycholesterol(24S-OH), 25-hyroxycholesterol (25-OHC), and 27-hydroxycholesterol (27-OHC),in plasma were quantified by gas chromatography coupled with mass spectrometry.Results: In RBCs and plasma of AD patients, a significant decrease of glutathione peroxidase (GPx)activity was detected associated with raised levels of malondialdehyde (MDA). A decreased level oflanosterol and an accumulation of 7β-OHC, 24S-OHC, 27-OHC, and 25-OHC that were higher inplasma of AD patients, compared to controls, were also observed in AD patients. Mini-Mental State Examination(MMSE) score was correlated with MDA and conjugated dienes (CD) levels in plasma. Besides,the MDA level in RBCs was correlated with 7β-OHC. Binary logistic regression revealed an associationbetween GPx activity and AD (OR=0.895, 95%CI: 0.848-0.945. P<0.001).Conclusion: Our data consolidate the relationship between the rupture of redox homeostasis and lipidand cholesterol oxidation in AD.

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《Current Alzheimer research》 |2020年第9期|823-834|共12页
作者
Amira Zarrouk; Souha Hammouda; Imen GhzaielSonia HammamiWided KhamlaouiSamia H. AhmedGérard LizardMohamed Hammami;
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作者单位

Faculty of Medicine, University Monastir;

University Bourgogne Franche-Comté, Team, Biochemistry of the Peroxisome, Inflammation and Lipid;

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正文语种英语
中图分类神经病学与精神病学;
关键词
Alzheimer`s disease; oxidative stress; oxysterols; lipid peroxidation; antioxydant enzymes; cholesterol;

Association Between Oxidative Stress and Altered Cholesterol Metabolism in Alzheimer’s Disease Patients Bentham Science

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