Antimicrobial Hybrid Amphiphile via Dynamic Covalent Bonds Enables Bacterial Biofilm Dispersal and Bacteria Eradication

Yizhou Zhan; Xiaowen Hu; Yuanfeng LiYaran WangHua ChenCalvin Andeve OmoloThirumala GovenderHuaping LiFan HuangLinqi ShiXiaoli HuYong Liu

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Antimicrobial Hybrid Amphiphile via Dynamic Covalent Bonds Enables Bacterial Biofilm Dispersal and Bacteria Eradication

机译：Antimicrobial Hybrid Amphiphile via Dynamic Covalent Bonds Enables Bacterial Biofilm Dispersal and Bacteria Eradication

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To tackle the problems caused by bacterial biofilms, herein, this study reportsan antimicrobial hybrid amphiphile (aHA) via dynamic covalent bonds foreradicating staphylococcal biofilms. aHA is synthesized via iminoboronateester formation between DETA NONOate (nitric oxide donor),3 4-dihydroxybenaldehyde, and phenylboronic acid-modified ciprofloxacin(Cip). aHA can self-assemble in aqueous solution with an ultra-small criticalaggregation concentration of 3.80 × 10~(-5) mm and high drug loading content of73.8%. The iminoboronate ester is sensitive to the acidic and oxidative biofilmmicroenvironment,liberating nitric oxide and Cip that can synergisticallyeradicate bacterial biofilms. To this end, aHA assemblies efficiently eradicatestaphylococcal infections and ameliorate inflammation in the murine peritonealand subcutaneous infection models without any notable side effectson normal tissues. Collectively, the aHA assemblies may provide a facile andefficient alternative to the current development of anti-biofilm therapies.

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《Advanced functional materials》 |2023年第23期|2214299.1-2214299.15|共15页
作者
Yizhou Zhan; Xiaowen Hu; Yuanfeng LiYaran WangHua ChenCalvin Andeve OmoloThirumala GovenderHuaping LiFan HuangLinqi ShiXiaoli HuYong Liu;
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Discipline of Pharmaceutical SciencesCollege of Health SciencesUniversity of KwaZulu-NatalDurban 4000, South Africa;

Translational Medicine Laboratorythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou InstituteUniversity of Chinese Academy of SciencesZhejiang 325001, China;

Key Laboratory of Radiopharmacokinetics for Innovative DrugsChinese Academy of Medical Sciences, and Institute of RadiationMedicineChinese Academy of Medical Sciences & Peking Union Medical CollegeTianjin 300192, ChinaKey Laboratory of Functional Polymer Materials of Ministry of EducationInstitute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071, ChinaDepartment of Gynecologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou, Zhejiang 325035, ChinaTranslational Medicine Laboratorythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou InstituteUniversity of Chinese Academy of SciencesZhejiang 325001, China School of Materials Science and Optoelectronic TechnologyUniversity of Chinese AcaDepartment of PharmaceuticsSchool of Pharmacy and Health SciencesUnited States International University-AfricaNairobi 14634-00800, Kenya;

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biofilm matrix; drug-resistance; mechanism study; stimuli-release; supramolecular self-assemblies;

Antimicrobial Hybrid Amphiphile via Dynamic Covalent Bonds Enables Bacterial Biofilm Dispersal and Bacteria Eradication

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