The Complications of Aspergillus fumigatus Sensitization in Patients with Asthma

Vida Mortezaee; Seyed Alireza Mahdaviani; Maryam Sadat MirenayatMihan PourabdollahMaryam HassanzadPayam MehrianMaedeh MalekiJalal HeshmatniaAtefeh FakharianFelix BongominAlessandro C. PasqualottoMohammad Taghi Hedayati

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The Complications of Aspergillus fumigatus Sensitization in Patients with Asthma

机译：The Complications of Aspergillus fumigatus Sensitization in Patients with Asthma

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Background: Two major complications of Aspergillus sensitization in patients with asthma, including severe asthma with fungal sensitization (SAFS) and asthma associated with fungal sensitization (AAFS), have been recently described. Objectives: In the present study, we aimed to evaluate the prevalence of SAFS and AAFS in Iranian patients with asthma. Methods: Two hundred consecutive outpatients aged ≥ 18 years with moderate to severe allergic asthma, referred to a pulmonary subspecialty hospital (Tehran, Iran) for 25 months, were included in the study. Skin prick test (SPT), total IgE (tIgE), and specific IgE (sIgEAf) and IgG against Aspergillus fumigatus (sIgGAf) were determined for all subjects. Comprehensive criteria were applied for the diagnosis of SAFS and AAFS. Results: Of 200 included patients, 103 (51.5%) and 97 (48.5%) were with moderate and severe asthma, respectively. Of these patients, 111 (55.5%) were female. The mean (range) of age was 45.8 (18 - 78) years. Of 200 patients, 27 (13.5%), 22 (11.0%), 114 (57.0%), and 131 (65.5%) were positive for Aspergillus SPT, sIgEAf, sIgGAf, and tIgE, respectively. The overall prevalence of SAFS in patients with severe asthma and AASF in patients with moderate asthma were 7.2% (7/97) and 3.9% (4/103), respectively. Conclusions: According to the findings, the prevalence of SAFS and AAFS in Iranian patients with severe and moderate allergic asthma was lower than the previously published global data. This low-prevalence reported rate may be due to the fact that we applied strict criteria in the present study.

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《Jundishapur Journal of Microbiology》 |2020年第3期|1-6|共6页
作者
Vida Mortezaee; Seyed Alireza Mahdaviani; Maryam Sadat MirenayatMihan PourabdollahMaryam HassanzadPayam MehrianMaedeh MalekiJalal HeshmatniaAtefeh FakharianFelix BongominAlessandro C. PasqualottoMohammad Taghi Hedayati;
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Department of Medical Mycology, Mazandaran University of Medical Sciences;

Paediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences;

Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NIRTLD), Shahid Beheshti University of Medical SciencesChronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical SciencesDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Gulu UniversitySanta Casa de Misericórdia de Porto Alegre/ Universidade Federal de Ciências da Saúde de Porto AlegreInvasive Fungi Research Center, Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences;

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正文语种英语
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Asthma; Severe Asthma with Fungal sensitization; Asthma Associated with Fungal Sensitization; Aspergillus Sensitization;

The Complications of Aspergillus fumigatus Sensitization in Patients with Asthma

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