Long-Term Exposure to Neonicotinoid Insecticide Acetamiprid at Environmentally Relevant Concentrations Impairs Endocrine Functions in Zebrafish:Bioaccumulation,Feminization,and Transgenerational Effects

Xue Ma; Jingjing Xiong; Huizhen Li

首页> 外文期刊>Environmental Science & Technology: ES&T >Long-Term Exposure to Neonicotinoid Insecticide Acetamiprid at Environmentally Relevant Concentrations Impairs Endocrine Functions in Zebrafish:Bioaccumulation,Feminization,and Transgenerational Effects

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Long-Term Exposure to Neonicotinoid Insecticide Acetamiprid at Environmentally Relevant Concentrations Impairs Endocrine Functions in Zebrafish:Bioaccumulation,Feminization,and Transgenerational Effects

机译：Long-Term Exposure to Neonicotinoid Insecticide Acetamiprid at Environmentally Relevant Concentrations Impairs Endocrine Functions in Zebrafish:Bioaccumulation,Feminization,and Transgenerational Effects

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Neonicotinoid insecticides have attracted worldwide attention due to their ubiquitous occurrence and detrimental effects on aquatic organisms,yet their impacts on fish reproduction during long-term exposure remain unknown.Here,zebrafish(F0) were exposed to a neonicotinoid,acetamiprid,at 0.19-1637 μg/L for 154 d.Accumulation and biotransformation of acetamiprid were observed in adult fish,and the parent compound and its metabolite(acetamiprid-N-desmethyl) were transferred to their offspring.Acetamiprid caused slight survival reduction and significant feminization in F0 fish even at the lowest concentration.Hormone levels in F0 fish were remarkedly altered,that is,gonad 17/?-estradiol(E2) significantly increased,while androstenedione decreased.The corresponding transcription of steroidogenic genes(ar,cypl9b,fshfi,gnrh2,gnrh3,and Ihp) were significantly upregulated in the brain and gonad of the females but downregulated in the males.The vtgl gene expression in the liver of male fish was also upregulated.In addition to F0 fish,parental exposure to acetamiprid decreased hatchability and enhanced malformation of Fl embryos.Chronic exposure to acetamiprid at environmentally relevant concentrations altered hormone production and the related gene expression of the hypothalamic-pituitary-gonad(HPG) axis in a sex-dependent way,caused feminization and reproductive dysfunction in zebrafish,and impaired production and development of their offspring.

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《Environmental Science & Technology: ES&T》 |2022年第17期|12494-12505|共12页
作者
Xue Ma; Jingjing Xiong; Huizhen Li;
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作者单位

Guangdong Provincial Key Laboratory of Environmental Pollution and Health,School of Environment,Jinan University,Guangzhou SI 1443,China;

Guangdong Provincial Key Laboratory of Environmental Pollution and Health,School of Environment,Jinan University,Guangzhou 511443,China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
life-time exposure; endocrine disruption; sex hormones; steroidogenic genes; feminization; transgenerational effects;

Long-Term Exposure to Neonicotinoid Insecticide Acetamiprid at Environmentally Relevant Concentrations Impairs Endocrine Functions in Zebrafish:Bioaccumulation,Feminization,and Transgenerational Effects

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