Biomimetic Natural Biopolymer-Based Wet-Tissue Adhesive for Tough Adhesion, Seamless Sealed, Emergency/Nonpressing Hemostasis, and Promoted Wound Healing

Wen Yang; Xinyi Kang; Xu GaoYan ZhuangCaixai FanHe ShenYanyan ChenJianwu Dai

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Biomimetic Natural Biopolymer-Based Wet-Tissue Adhesive for Tough Adhesion, Seamless Sealed, Emergency/Nonpressing Hemostasis, and Promoted Wound Healing

机译：Biomimetic Natural Biopolymer-Based Wet-Tissue Adhesive for Tough Adhesion, Seamless Sealed, Emergency/Nonpressing Hemostasis, and Promoted Wound Healing

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摘要

Bioadhesives have been used in clinics among the most prospective alternativesto sutures and staples for wound sealing and repairing; however, theygenerally have inadequate adhesion to wet surfaces, improper mechanicalstrength, poor hemostasis, and cytotoxicity. To address these challenges, arobust wet tissue adhesive based on collagen and starch materials (CoSt)is designed in this study. CoSt hydrogels integrate the feature of drainage,molecular penetration and strengthen cross-linking similar to mussel, ivy,and oyster glues, which remove interfacial water quickly, reinforce toughdissipation and involve multiple reversible dynamic interactions. Therefore,they form strong adhesion and sutureless sealing of injured tissues,accompanying actuate robust biointerfaces in direct contact with tissueliquids or blood, resolving the crucial impediments with sutures and commerciallyaccessible adhesives. The novel bioadhesive shows repeatablestrong wet tissue adhesiveness (62 ± 4.8 KPa), high sealing performance(153.2 ± 35.1 mmHg), fast self-healing ability, excellent injectability, and shapeadaptability. For different hemostatic needs in rat models of tail amputation,skin incision, severe liver, abdominal aorta, and transected nerve injuries, theCoSt hydrogel shows better hemostatic efficiency than fibrin glue becauseof the coordinate efficacy of tough wound sealing property, outstandingred blood cell arresting capability, and the activation of hemostatic barriermembrane. Moreover, in vivo investigation of the skin injury repair of the ratmodel validate that CoSt hydrogels accelerate wound healing and functionalrecovery via skin damage/defects. Tough wet adhesion, quick hemostasis,distinguished biocompatibility, suitability to match irregular-shaped targetsites, and good wound healing promotion of the CoSt hydrogel makes it aprospective bioadhesive for various biomedical applications.

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来源
《Advanced functional materials》 |2023年第6期|2211340.1-2211340.16|共16页
作者
Wen Yang; Xinyi Kang; Xu GaoYan ZhuangCaixai FanHe ShenYanyan ChenJianwu Dai;
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作者单位

School of Nano-Tech and Nano-Bionics University of Science and Technology of China Hefei 230026, China,Key Laboratory for Nano-Bio Interface Research Division of Nanobiomedicine Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Su;

Key Laboratory for Nano-Bio Interface Research Division of Nanobiomedicine Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou 215123, China;

Key Laboratory for Nano-Bio Interface Research Division of Nanobiomedicine Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou 215123, China,State Key Laboratory of Molecular Development Biology Institute of Genetics and Deve;

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正文语种英语
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bioadhesives; bionics; hemostasis; wet surface adhesions; wound repairs;

Biomimetic Natural Biopolymer-Based Wet-Tissue Adhesive for Tough Adhesion, Seamless Sealed, Emergency/Nonpressing Hemostasis, and Promoted Wound Healing

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