Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases

Song Yongfeng; Liu Junjun; Zhao KeGao LingZhao Jiajun

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Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases

机译：Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases

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摘要

High levels of cholesterol are generally considered to be associated with atherosclerosis. In the past two decades, however, a number of studies have shown that excess cholesterol accumulation in various tissues and organs plays a critical role in the pathogenesis of multiple diseases. Here, we summarize the effects of excess cholesterol on disease pathogenesis, including liver diseases, diabetes, chronic kidney disease, Alzheimer's disease, osteoporosis, osteoarthritis, pituitary-thyroid axis dysfunction, immune disorders, and COVID-19, while proposing that excess cholesterol-induced toxicity is ubiquitous. We believe this concept will help broaden the appreciation of the toxic effect of excess cholesterol, and thus potentially expand the therapeutic use of cholesterol-lowering medications.

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来源
《Cell metabolism》 |2021年第10期|1911-1925|共15页
作者
Song Yongfeng; Liu Junjun; Zhao KeGao LingZhao Jiajun;
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作者单位

Shandong Prov Hosp,Shandong First Med Univ;

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原文格式 PDF
正文语种英语
中图分类内分泌腺疾病及代谢病;
关键词
NONALCOHOLIC FATTY LIVER; BLOOD-BRAIN-BARRIER; DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY-HEART-DISEASE; CROWN-LIKE STRUCTURES; BONE-MINERAL DENSITY; DIETARY-CHOLESTEROL; LIPID-ACCUMULATION; DIABETIC MICE; UNITED-STATES;

Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases

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