Brief assessment of cognitive function in myotonic dystrophy: Multicenter longitudinal study using computer‐assisted evaluation

Gayle K. Deutsch; Katharine A. Hagerman; Jacinda SampsonGersham DentJeanne DekdebrunDana M. ParkerCharles A. ThorntonChad R. HeatwoleSub H. SubramonyAmi K. MankodiTetsuo AshizawaJeffrey M. StatlandW. David ArnoldRichard T. MoxleyJohn W. Day

首页> 外文期刊>Muscle and Nerve >Brief assessment of cognitive function in myotonic dystrophy: Multicenter longitudinal study using computer‐assisted evaluation

【24h】

Brief assessment of cognitive function in myotonic dystrophy: Multicenter longitudinal study using computer‐assisted evaluation

机译：Brief assessment of cognitive function in myotonic dystrophy: Multicenter longitudinal study using computer‐assisted evaluation

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Abstract Introduction/Aims Myotonic dystrophy type 1 (DM1) is known to affect cognitive function, but the best methods to assess central nervous system involvement in multicenter studies have not been determined. In this study our primary aim was to evaluate the potential of computerized cognitive tests to assess cognition in DM1. Methods We conducted a prospective, longitudinal, observational study of 113 adults with DM1 at six sites. Psychomotor speed, attention, working memory, and executive functioning were assessed at baseline, 3 months, and 12 months using computerized cognitive tests. Results were compared with assessments of muscle function and patient reported outcomes (PROs), including the Myotonic Dystrophy Health Index (MDHI) and the 5‐dimension EuroQol (EQ‐5D‐5L) questionnaire. Results Based on intraclass correlation coefficients, computerized cognitive tests had moderate to good reliability for psychomotor speed (0.76), attention (0.82), working memory speed (0.79), working memory accuracy (0.65), and executive functioning (0.87). Performance at baseline was lowest for working memory accuracy (P?

著录项

来源
《Muscle and Nerve》 |2022年第5期|560-567|共8页
作者
Gayle K. Deutsch; Katharine A. Hagerman; Jacinda SampsonGersham DentJeanne DekdebrunDana M. ParkerCharles A. ThorntonChad R. HeatwoleSub H. SubramonyAmi K. MankodiTetsuo AshizawaJeffrey M. StatlandW. David ArnoldRichard T. MoxleyJohn W. Day;
展开▼
作者单位

Department of Neurology and Neurological Sciences,Stanford University School of Medicine;

Biogen;

Department of Neurology,The University of Rochester Medical CenterDepartment of Neurology, Norman Fixel Center for Neurological Disorders,University of FloridaNational Institute of Neurological Disorders and StrokeDepartment of Neurology, Weill Cornell Medicine at Houston Methodist HospitalDepartment of Neurology, University of Kansas Medical CenterDepartments of Neurology, PM&R, Neuroscience and Physiology and Cell Biology,The Ohio State;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类人体生理学;
关键词
muscle disease; myotonic dystrophy type 1; neuropsychology; patient‐reported outcome; quality of life;

Brief assessment of cognitive function in myotonic dystrophy: Multicenter longitudinal study using computer‐assisted evaluation

摘要

著录项

相关主题

期刊订阅