Molecular aspects of fructose metabolism and metabolic disease

Herman Mark A.; Birnbaum Morris J.

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Molecular aspects of fructose metabolism and metabolic disease

机译：Molecular aspects of fructose metabolism and metabolic disease

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Excessive sugar consumption is increasingly considered as a contributor to the emerging epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet in the form of sucrose or high-fructose corn syrup, both of which comprise nearly equal amounts of glucose and fructose. The unique aspects of fructose metabolism and properties of fructose-derived metabolites allow for fructose to serve as a physiological signal of normal dietary sugar consumption. However, when fructose is consumed in excess, these unique properties may contribute to the pathogenesis of cardiometabolic disease. Here, we review the biochemistry, genetics, and physiology of fructose metabolism and consider mechanisms by which excessive fructose consumption may contribute to metabolic disease. Lastly, we consider new therapeutic options for the treatment of metabolic disease based upon this knowledge.

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《Cell metabolism》 |2021年第12期|2329-2354|共26页
作者
Herman Mark A.; Birnbaum Morris J.;
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作者单位

Div Endocrinol Metab & Nutr,Duke Univ;

Internal Med Res Unit,Pfizer;

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正文语种英语
中图分类内分泌腺疾病及代谢病;
关键词
FATTY LIVER-DISEASE; SUGAR-SWEETENED BEVERAGES; DE-NOVO LIPOGENESIS; ELEMENT-BINDING PROTEIN; INTESTINAL GLUCOSE-ABSORPTION; INDUCED INSULIN-RESISTANCE; HIGH-SUCROSE DIET; CORN SYRUP; ADIPOSE-TISSUE; TRANSCRIPTION FACTOR;

Molecular aspects of fructose metabolism and metabolic disease

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