Electrically Induced Bursting of Aqueous Capsules Made from Biopolymers: ‘Switching On’ the Release of Payloads

Ankit Gargava; Wenhao Xu; Srinivasa R. Raghavan

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Electrically Induced Bursting of Aqueous Capsules Made from Biopolymers: ‘Switching On’ the Release of Payloads

机译：Electrically Induced Bursting of Aqueous Capsules Made from Biopolymers: ‘Switching On’ the Release of Payloads

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The use of electric fields to stimulate the delivery of drugs or other activeingredients is of great interest for wearable electronics and other applications.Most attempts at electrically induced delivery with soft materials in waterhave focused on electronically conducting polymers (e.g., polypyrroles) orconductive nanocomposites (e.g., polymers with carbon nanotubes). Here,electrical responses are induced even in structures made from nonconductingbiopolymers that are widely available, biocompatible, and biodegradable.The materials studied here are spherical capsules created from the anionicpolysaccharide alginate by cross-linking with cations like Ca~（2+） or Cu~（2+）. Whenthese capsules are placed in an aqueous solution and subjected to an electricfield (direct current) of ≈8 V cm~（?1）, they deform within a couple of minutesand then burst and disintegrate into pieces within ≈5 min. Capsules acrossa range of length scales (200 μm to 2 cm) respond in the above manner, andthe electroresponse persists even if the capsules are embedded in a nonionicgel matrix. This electroresponse is due to electrophoretic migration ofcharged species (ions and/or polyelectrolyte chain-segments) within (or outof ) the capsules. In an alginate capsule, the cations are induced to migrateaway from the positive electrode, which creates a weakly cross-linked regionof the capsule that swells appreciably. This anisotropic swelling continuesuntil the capsule eventually bursts. Applications for electroresponsive capsulesthat highlight the spatial and temporal accuracy possible with an electricalstimulus are discussed. The bursting of capsules can be used to releasesolutes loaded inside these structures. Also, even the deformation of intactcapsules can be used to create electrically actuatable valves, where a liquidflows out through the valve only when a capsule plug is dislodged.

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《Advanced functional materials》 |2022年第51期|2206029.1-2206029.10|共10页
作者
Ankit Gargava; Wenhao Xu; Srinivasa R. Raghavan;
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Department of Chemical & Biomolecular EngineeringUniversity of MarylandCollege Park, MD 20742, USA,Department of Chemistry & BiochemistryUniversity of MarylandCollege Park, MD 20742, USA;

Department of Chemical & Biomolecular EngineeringUniversity of MarylandCollege Park, MD 20742, USA;

Department of Chemistry & BiochemistryUniversity of MarylandCollege Park, MD 20742, USA;

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正文语种英语
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alginates; electrically actuated valves; electrically induced drug deliveries; electroresponses; smart capsules;

Electrically Induced Bursting of Aqueous Capsules Made from Biopolymers: ‘Switching On’ the Release of Payloads

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