The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort

Loef M.; van de Stadt L.; Bohringer S.Bay-Jensen A. -c.Mobasheri A.Larkin J.Lafeber F. P. J. G.Blanco F. J.Haugen I. K.Berenbaum F.Giera M.Ioan-Facsinay A.Kloppenburg M.

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The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort

机译：The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort

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Objective: To investigate the association of the lipidomic profile with osteoarthritis (OA) severity, considering the outcomes radiographic knee and hand OA, pain and function. Design: We used baseline data from the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH) cohort, comprising persons with knee OA fulfilling the clinical American College of Rheumatology classification criteria. Radiographic knee and hand OA severity was quantified with Kellgren-Lawrence sum scores. Knee and hand pain and function were assessed with validated questionnaires. We quantified fasted plasma higher order lipids and oxylipins with liquid chromatography with tandem mass spectrometry (LC-MS/MS)-based platforms. Using penalised linear regression, we assessed the variance in OA severity explained by lipidomics, with adjustment for clinical covariates (age, sex, body mass index (BMI) and lipid lowering medication), measurement batch and clinical centre. Results: In 216 participants (mean age 66 years, mean BMI 27.3 kg/m2, 75% women) we quantified 603 higher order lipids (triacylglycerols, diacylglycerols, cholesteryl esters, ceramides, free fatty acids, sphingomyelins, phospholipids) and 28 oxylipins. Lipidomics explained 3% and 2% of the variance in radiographic knee and hand OA severity, respectively. Lipids were not associated with knee pain or function. Lipidomics accounted for 12% and 6% of variance in hand pain and function, respectively. The investigated OA severity outcomes were associated with the lipidomic fraction of bound and free arachidonic acid, bound palmitoleic acid, oleic acid, linoleic acid and docosapentaenoic acid. Conclusions: Within the APPROACH cohort lipidomics explained a minor portion of the variation in OA severity, which was most evident for the outcome hand pain. Our results suggest that eicosanoids may be involved in OA severity. (c) 2022 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.

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《Osteoarthritis and cartilage》 |2022年第8期|1062-1069|共8页
作者
Loef M.; van de Stadt L.; Bohringer S.Bay-Jensen A. -c.Mobasheri A.Larkin J.Lafeber F. P. J. G.Blanco F. J.Haugen I. K.Berenbaum F.Giera M.Ioan-Facsinay A.Kloppenburg M.;
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Leiden University,Leiden Univ;

Med Stat,Leiden Univ;

Regenerat Med,State Res Inst Ctr Innovat MedGlaxoSmithKline USARheumatol & Clin Immunol,UMC UtrechtServ Reumatol,Hosp Univ CorunaDiv Rheumatol & Res,Diakonhjemmet HospSt Antoine Hosp,Sorbonne UnivCtr Prote & Metabol,Leiden Univ;

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正文语种英语
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Lipids; Osteoarthritis; Radiography; Pain; Function; CLASSIFICATION; CRITERIA; INDEX;

The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort

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