Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants

Vimberg Vladimir; Cavanagh Jorunn Pauline; Novotna MichaelaLenart JakubBich Nguyen Thi NgocVesela JanaPain MariaKoberska MarketaNovotna Gabriela Balikova

首页> 外文期刊>Antimicrobial agents and chemotherapy. >Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants

【24h】

Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants

机译：Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Vga(A) protein variants confer different levels of resistance to lincosamides, streptogramin A, and pleuromutilins (LSAP) by displacing antibiotics from the ribosome. Here, we show that expression of vga(A) variants from Staphylococcus haemolyticus is regulated by cis-regulatory RNA in response to the LSAP antibiotics by the mechanism of ribosome-mediated attenuation. The specificity of induction depends on Vga(A)-mediated resistance rather than on the sequence of the riboregulator. Fine tuning between Vga(A) activity and its expression in response to the antibiotics may contribute to the selection of more potent Vga(A) variants because newly acquired mutation can be immediately phenotypically manifested.

著录项

来源
《Antimicrobial agents and chemotherapy.》 |2020年第11期|共11页
作者
Vimberg Vladimir; Cavanagh Jorunn Pauline; Novotna MichaelaLenart JakubBich Nguyen Thi NgocVesela JanaPain MariaKoberska MarketaNovotna Gabriela Balikova;
展开▼
作者单位

Czech Acad Sci, Inst Microbiol, Vestec, Czech Republic;

UiT Arctic Univ Norway, Dept Clin Med, Tromso, Norway;

Univ Hosp North Norway, Dept Pediat, Tromso, Norway;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类治疗学;
关键词
ABCF proteins; Staphylococcus haemolyticus; Vga(A); antibiotic resistance; clindamycin; lincosamides; pleuromutilins; regulation of gene expression; ribosome-mediated attenuation;

Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants

摘要

著录项

相关主题

期刊订阅