...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European journal of neuroscience. >The development of bi‐directionally coupled self‐organizing neurovascular networks captures orientation‐selective neural and hemodynamic cortical responses
【24h】

The development of bi‐directionally coupled self‐organizing neurovascular networks captures orientation‐selective neural and hemodynamic cortical responses

机译：The development of bi‐directionally coupled self‐organizing neurovascular networks captures orientation‐selective neural and hemodynamic cortical responses

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Abstract Networks of neurons are the primary substrate of information processing. Conversely, blood vessels in the brain are generally viewed to have physiological functions unrelated to information processing, such as the timely supply of oxygen, and other nutrients to the neural tissue. However, recent studies have shown that cerebral microvessels, like neurons, exhibit tuned responses to sensory stimuli. Tuned neural responses to sensory stimuli may be enhanced with experience‐dependent Hebbian plasticity and other forms of learning. Hence, it is possible that the microvascular network might also be subject to some form of competitive learning rules during early postnatal development such that its fine‐scale structure becomes optimized for metabolic delivery to a given neural micro‐architecture. To explore the possibility of adaptive lateral interactions and tuned responses in cerebral microvessels, we modelled the cortical neurovascular network by interconnecting two laterally connected self‐organizing networks. The afferent and lateral connections of the neural and vascular networks were defined by trainable weights. By varying the topology of lateral connectivity in the vascular network layer, we observed that the partial correspondence of feature selectivity between neural and hemodynamic responses could be explained by lateral coupling across local blood vessels such that the central domain receives an excitatory drive of more blood flow and a distal surrounding region where blood flow is reduced. Critically, our simulations suggest a new role for feedback from the vascular to the neural network because the radius of vascular perfusion determines whether the cortical neural map develops into a clustered vs. salt‐and‐pepper organization.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号