Engineering Bacteria-Activated Multifunctionalized Hydrogel for Promoting Diabetic Wound Healing

Lu Yifei; Li Haisheng; Wang JingYao MengyunPeng YuanLiu TengfeiLi ZhouLuo GaoxingDeng Jun

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Engineering Bacteria-Activated Multifunctionalized Hydrogel for Promoting Diabetic Wound Healing

机译：Engineering Bacteria-Activated Multifunctionalized Hydrogel for Promoting Diabetic Wound Healing

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Engineering therapeutic angiogenesis in impaired tissues is critical for chronic wound healing. Materials can be engineered to deliver specific biological cues that enhance angiogenesis. However, currently available materials have limitations for use in angiogenesis engineering since the complex inflammation environment of wounds requires spatiotemporal control. Immune cells are the central component of wound microenvironment and orchestrate immune responses to wound healing. This study presents a novel approach of using a delivery system comprising living Lactococcus, incorporated in a heparin-poloxamer thermoresponsive hydrogel, designed to bioengineer the wound microenvironment and enhance the angiogenesis in a highly dynamic-temporal manner. The living system can produce and protect vascular endothelial growth factor (VEGF) to increase proliferation, migration, and tube formation of endothelial cells, as well as secrete lactic acid to shift macrophages toward an anti-inflammatory phenotype, resulting in successful angiogenesis in diabetic wounds. Further, the delivery system confines the bacterial population to wounds, thereby minimizing the risk of systemic toxicities. Therefore, this living hydrogel system can be harnessed for safe and efficient delivery of therapeutics that drive the wound microenvironment toward rapid healing and may serve as a promising scaffold in regenerative medicine.

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《Advanced functional materials》 |2021年第48期|2105749.1-2105749.13|共13页
作者
Lu Yifei; Li Haisheng; Wang JingYao MengyunPeng YuanLiu TengfeiLi ZhouLuo GaoxingDeng Jun;
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作者单位

Third Mil Med Univ, Army Med Univ, State Key Lab Trauma Burn & Combined Injury, Inst Burn Res,Chongqing Key Lab Dis Prote, Chongqing 400038, Peoples R China;

Third Mil Med Univ, Army Med Univ, Dept Microbiol, Chongqing 400038, Peoples R China;

Shanghai Jiao Tong Univ, Shanghai Ninth Peoples Hosp, Dept Plast & Reconstruct Surg, Shanghai 200011, Peoples R ChinaUniv Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing Key Lab Micronano Energy & Sensor, CAS Ctr Excellence Nanosci, Beijing 100083, Peoples R China|Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Plast Surg,State Key Lab Trauma Burns;

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正文语种英语
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angiogenesis; drug delivery; living hydrogels; synthetic biology; wound healing;

Engineering Bacteria-Activated Multifunctionalized Hydrogel for Promoting Diabetic Wound Healing

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