Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway

Liu Huazhen; Chen Yonger; Wen YifanZhu ShuminHuang SongHe LianHou ShaozhenLai XiaopingChen ShuxianDai ZhenhuaLiang Jian

首页> 外文期刊>Journal of Agricultural and Food Chemistry >Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway

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Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway

机译：Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway

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We aimed to investigate whether phloridzin could alleviate nonalcoholic fatty liver disease (NAFLD) in mice, which was induced by feeding a high-fat diet (HFD). We initially analyzed the effect of phloridzin on alleviating HFD-induced NAFLD in CS7BL/6J mice and oleic acid (OA)-stimulated human normal liver L-02 cells (L02). Then, we investigated the mechanism of phloridzin on the mTORC1/sterol-regulatory element-binding protein-1c (SREBP-1c) signaling pathway by siRNA analysis, qRT-PCR, flow cytometry, and western blot analysis in vivo and in vitro. The results revealed that phloridzin significantly inhibited the increase in body weight, alleviated abnormal lipid metabolism, and decreased lipid biosynthesis and insulin resistance. Moreover, phloridzin augmented the number of CD8(+)CD122(+)PD-1(+) Tregs and CD4(+)FoxP3(+) Tregs in HFD-fed CS7BL/6J mice and HFD-fed aP2-SREBF1c mice and downregulated the mTORC1/SREBP-1c signaling pathway-related protein expressions in vivo and in vitro. Furthermore, phloridzin reduced the expression of SREBP-1c in SREBP-1c-RNAi-lentivirus-transfected L02 cells and reversed the SREBP-1c expression in HFD-fed aP2-SREBF1c transgenic mice. Phloridzin ameliorates lipid accumulation and insulin resistance via inhibiting the mTORC1/SREBP-1c pathways. These results indicated that phloridzin may actively ameliorate NAFLD.

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《Journal of Agricultural and Food Chemistry》 |2021年第31期|8671-8683|共13页
作者
Liu Huazhen; Chen Yonger; Wen YifanZhu ShuminHuang SongHe LianHou ShaozhenLai XiaopingChen ShuxianDai ZhenhuaLiang Jian;
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作者单位

Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China;

Guangdong Food & Drug Vocat Coll, Guangzhou 510520, Guangdong, Peoples R China;

Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou 510080, Guangdong, Peoples R ChinaGuangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou 510405, Guangdong, Peoples R China;

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正文语种英语
中图分类营养卫生、食品卫生;农业科学;
关键词
mTORC1; NAFLD; phloridzin; Treg; SREBP-1c;

Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway

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