Urinary titin in myotonic dystrophy type 1

Dávid Varga; Brigitta Perecz; Krisztina Fül?pAndrea SiposJózsef Vlagyimir JanszkyNándor HajdúEndre Pál

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Urinary titin in myotonic dystrophy type 1

机译：Urinary titin in myotonic dystrophy type 1

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Abstract Introduction/Aims Urinary titin, an easy‐to‐obtain marker, has been investigated in muscular dystrophies, but not in myotonic dystrophy type 1 (DM1). We investigated the role of titin as a biomarker of muscle injury in DM1. Methods We compared the urinary titin N‐fragment/creatinine ratio in 29 patients with DM1 vs. 30 healthy controls. We also recorded clinical data such as muscle strength, serum creatine kinase, DM1‐related outcome measures, and the 20‐item DM1‐activ questionnaire. The severity of the disease was graded using the Muscular Impairment Rating Scale (MIRS). Results The titin/creatinine ratio was significantly higher in the urine samples of DM1 patients than of healthy controls (median?± mean absolute deviation [MAD]: 39.313?±?26.546 vs. 6.768?±?5.245?pmol/mg creatinine; P?

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来源
《Muscle and Nerve》 |2023年第2期|215-218|共4页
作者
Dávid Varga; Brigitta Perecz; Krisztina Fül?pAndrea SiposJózsef Vlagyimir JanszkyNándor HajdúEndre Pál;
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作者单位

Department of Neurology,University of Pécs, Medical School;

Department of Pathology, Neuropathology Unit,University of Pécs, Medical School;

Institute of Psychology, ELTE,E?tv?s Loránd University;

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正文语种英语
中图分类人体生理学;
关键词
muscle impairment rating scale; myotonic dystrophy type 1; urinary titin;

Urinary titin in myotonic dystrophy type 1

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