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首页> 外文期刊>Advanced functional materials >Bandgap Modulation and Lipid Intercalation Generates Ultrabright D–A–D-Based Zwitterionic Small-Molecule Nanoagent for Precise NIR-Ⅱ Excitation Phototheranostic Applications
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Bandgap Modulation and Lipid Intercalation Generates Ultrabright D–A–D-Based Zwitterionic Small-Molecule Nanoagent for Precise NIR-Ⅱ Excitation Phototheranostic Applications

机译：Bandgap Modulation and Lipid Intercalation Generates Ultrabright D–A–D-Based Zwitterionic Small-Molecule Nanoagent for Precise NIR-Ⅱ Excitation Phototheranostic Applications

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摘要

Conjugated small-molecule (CSM) phototheranostic agents that operate inthe second near-infrared (NIR-Ⅱ) region have garnered significant attentionin the field of biomedicine. However, a lack of fluorescence-emittingability hinders their use in precise fluorescence imaging (FI)-guided photothermaltherapy (PTT). Herein, a two-pronged fluorescence intensificationstrategy—molecular engineering for rational bandgap modulation andlipid-intercalation to combat fluorescence quenching—is used to developNIR-Ⅱ-excited ultrabright donor–acceptor–donor-based (D–A–D)-basedzwitterionic CSM nanoagent for tumor phototheranostics. The molecularengineering strategy produces the NIR-Ⅱ-excited D–A–D-based zwitterionicfluorophore (BTFQ) that exhibits a high NIR-Ⅱ fluorescencequantum yield (QY = 0.65%) in dichloromethane. More importantly, BTFQcomplexed with liposome (DMPC) to form the zwitterion–liposome nanoagent(BTFQ/DMPC) shows a negligible loss of QY (0.63%) in aqueousmedia. Moreover, because BTFQ/DMPC possesses excellent photothermalconversion efficiency (PCE = 30.8%) performance, it can be used to realizeefficient in vivo 1064 nm single-photon high-resolution NIR-Ⅱ FI guidedNIR-Ⅱ PTT. This study introduces a new avenue for the developmentof NIR-Ⅱ-excited NIR-Ⅱ FI/PTT agents for precise and effective tumortreatment.

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