Nanoheterojunction Engineering Enables NIR-Ⅱ-Triggered Photonic Hyperthermia and Pyroelectric Catalysis for Tumor-Synergistic Therapy

Shan Zhang; Lina Wu; Wenqiang ShiJunchang QinWei FengYu ChenRuifang Zhang

首页> 外文期刊>Advanced functional materials >Nanoheterojunction Engineering Enables NIR-Ⅱ-Triggered Photonic Hyperthermia and Pyroelectric Catalysis for Tumor-Synergistic Therapy

【24h】

Nanoheterojunction Engineering Enables NIR-Ⅱ-Triggered Photonic Hyperthermia and Pyroelectric Catalysis for Tumor-Synergistic Therapy

机译：Nanoheterojunction Engineering Enables NIR-Ⅱ-Triggered Photonic Hyperthermia and Pyroelectric Catalysis for Tumor-Synergistic Therapy

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Photodynamic therapy (PDT) as a non-invasive strategy shows high promisein cancer treatment. However, owing to the hypoxic tumor microenvironmentand light irradiation-mediated rapid electron–hole pair recombination,the therapeutic efficacy of PDT is dramatically discounted by limited reactiveoxygen species (ROS) generation. Herein, a multifunctional theranosticnanoheterojunction is rationally developed, in which 2D niobium carbide(Nb_2C) Mxene is in situ grown with barium titanate (BTO) to generate arobust photo-pyroelectric catalyst, termed as BTO@Nb2C nanosheets, forenhanced ROS production, originating from the effective electron–holepair separation induced by the pyroelectric effect. Under the second nearinfrared(NIR-Ⅱ) laser irradiation, Nb_2C Mxene core-mediated photonichyperthermia regulates temperature variation around BTO shells facilitatingthe electron–hole spatial separation, which reacts with the surroundingO_2 and H_2O molecules to yield toxic ROS, achieving a synergetic effect bymeans of combinaterial photothermal therapy with pyrocatalytic therapy.Correspondingly, the engineered BTO@Nb2C composite nanosheets featurebenign biocompatibility and high antitumor efficiency with the tumorinhibitionrate of 94.9% in vivo, which can be applied as an imaging-guidedreal-time non-invasive synergetic dual-mode therapeutic nanomedicine forefficient tumor nanotherapy.

著录项

来源
《Advanced functional materials》 |2023年第29期|2302360.1-2302360.14|共14页
作者
Shan Zhang; Lina Wu; Wenqiang ShiJunchang QinWei FengYu ChenRuifang Zhang;
展开▼
作者单位

Department of UltrasoundThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052, P. R. China;

Materdicine LabSchool of Life SciencesShanghai UniversityShanghai 200444, P. R. China;

Department of CardiologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052, P. R. China;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
nanoheterojunctions; photonic hyperthermia; pyrocatalytic therapy; ROS generation;

Nanoheterojunction Engineering Enables NIR-Ⅱ-Triggered Photonic Hyperthermia and Pyroelectric Catalysis for Tumor-Synergistic Therapy

摘要

著录项

相关主题

期刊订阅