Separation and Detection of Tyrosine and Phenylalanine‐derived Oxidative Stress Biomarkers Using Microchip Electrophoresis with Electrochemical Detection

Dhanushka B. Weerasekara; Susan M. Lunte

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Separation and Detection of Tyrosine and Phenylalanine‐derived Oxidative Stress Biomarkers Using Microchip Electrophoresis with Electrochemical Detection

机译：Separation and Detection of Tyrosine and Phenylalanine‐derived Oxidative Stress Biomarkers Using Microchip Electrophoresis with Electrochemical Detection

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Abstract A method for the determination of selected aromatic amino acid biomarkers of oxidative stress using microchip electrophoresis with electrochemical detection is described. The separation of the major reaction products of phenylalanine and tyrosine with reactive nitrogen and oxygen species was accomplished using ligand exchange micellar electrokinetic chromatography with a PDMS/glass hybrid chip. Electrochemical detection was achieved using a pyrolyzed photoresist film working electrode. The system was evaluated for the analysis of the products of the Fenton reaction with tyrosine and phenylalanine, and the reaction of peroxynitrite with tyrosine.

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来源
《Electroanalysis》 |2022年第12期|1913-1927|共15页
作者
Dhanushka B. Weerasekara; Susan M. Lunte;
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University of Kansas;

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正文语种英语
中图分类电化学、电解、磁化学;
关键词
reactive nitrogen and oxygen species; microchip electrophoresis with electrochemical detection; hydroxyl radical; peroxynitrite; tyrosine;

Separation and Detection of Tyrosine and Phenylalanine‐derived Oxidative Stress Biomarkers Using Microchip Electrophoresis with Electrochemical Detection

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