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首页> 外文期刊>Nature immunology >An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells
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An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells

机译:An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells

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摘要

Reboldi and colleagues show that high-cholesterol diets influence IgA secretion. Cholesterol-derived metabolites act on plasma cell GPR183 receptors to alter cell positioning of IgA+ plasma cells within the lamina propria and suppress antibody responses to intestinal pathogens.

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