Imipenem-Relebactam Susceptibility and Genotypic Characteristics of Carbapenem-Resistant Enterobacterales Identified during Population-Based Surveillance

Sam Horwich-Scholefield; Tyler Lloyd; Vici VargheseEmily YetteSra HuangMark Pori

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Imipenem-Relebactam Susceptibility and Genotypic Characteristics of Carbapenem-Resistant Enterobacterales Identified during Population-Based Surveillance

机译：Imipenem-Relebactam Susceptibility and Genotypic Characteristics of Carbapenem-Resistant Enterobacterales Identified during Population-Based Surveillance

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Laboratories submit all carbapenem-resistant Enterobacter, Escherichia coli, and Klebsiella species to the Alameda County Public Health Department (ACPHD). ACPHD evaluated 75 isolates submitted during 9 months for susceptibility to imipenem-relebactam (I-R) and, using whole-genome sequencing, identified beta-lactamase genes. Of 60 (80%) isolates susceptible to I-R, 8 (13%) had detectable carbapenemase genes, including 4 KPC, two NDM, and two OXA-48-like; we described the relationship between the presence of beta-lactamase resistance genes and susceptibility to I-R.

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《Antimicrobial agents and chemotherapy.》 |2021年第11期|e02288-e2320|共33页
作者
Sam Horwich-Scholefield; Tyler Lloyd; Vici VargheseEmily YetteSra HuangMark Pori;
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作者单位

Alameda County Public Health Department, San Leandro, California, USA;

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原文格式 PDF
正文语种英语
中图分类治疗学;
关键词
beta-lactamase inhibitor; NDM; carbapenem resistance; imipenem-relebactam; whole-genome sequencing;

Imipenem-Relebactam Susceptibility and Genotypic Characteristics of Carbapenem-Resistant Enterobacterales Identified during Population-Based Surveillance

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