Amplification of Cerenkov Luminescence Using Semiconducting Polymers for Cancer Theranostics

Zachary T. Rosenkrans; Jessica C. Hsu; Eduardo Aluicio-SarduyTodd E. BarnhartJonathan W. EngleWeibo Cai

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Amplification of Cerenkov Luminescence Using Semiconducting Polymers for Cancer Theranostics

机译：Amplification of Cerenkov Luminescence Using Semiconducting Polymers for Cancer Theranostics

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The therapeutic efficacy of photodynamic therapy is limited by the abilityof light to penetrate tissues. Due to this limitation, Cerenkov luminescence(CL) from radionuclides has recently been proposed as an alternative lightsource in a strategy referred to as Cerenkov radiation-induced therapy(CRIT). Semiconducting polymer nanoparticles (SPNs) have ideal opticalproperties, such as large absorption cross-sections and broad absorbance,which can be utilized to harness the relatively weak CL produced byradionuclides. SPNs can be doped with photosensitizers and have ≈100%energy transfer efficiency by multiple energy transfer mechanisms. Herein,an optimized photosensitizer-doped SPN is investigated as a nanosystemto harness and amplify CL for cancer theranostics. It is found that semiconductingpolymers significantly amplify CL energy transfer efficiency.Bimodal positron emission tomography (PET) and optical imaging studiesshow high tumor uptake and retention of the optimized SPNs whenadministered intravenously or intratumorally. Lastly, it is found that photosensitizer-doped SPNs have excellent potential as a cancer theranosticsnanosystem in an in vivo tumor therapy study. This study shows that SPNsare ideally suited to harness and amplify CL for cancer theranostics, whichmay provide a significant advancement for CRIT that are unabated by tissuepenetration limits.

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《Advanced functional materials》 |2023年第33期|2302777.1-2302777.10|共10页
作者
Zachary T. Rosenkrans; Jessica C. Hsu; Eduardo Aluicio-SarduyTodd E. BarnhartJonathan W. EngleWeibo Cai;
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作者单位

Department of Pharmaceutical SciencesUniversity of Wisconsin-Madison600 Highland Ave., K6/562, Madison, WI 53792, USA;

Departments of Radiology and Medical PhysicsUniversity of Wisconsin-MadisonMadison, WI 53705, USA;

Departments of Radiology and Medical PhysicsUniversity of Wisconsin-MadisonMadison, WI 53705, USA,Carbone Cancer CenterUniversity of Wisconsin-MadisonMadison, WI 53705, USADepartment of Pharmaceutical SciencesUniversity of Wisconsin-Madison600 Highland Ave., K6/562, Madison, WI 53792, USA,Department of Pharmaceutical SciencesUniversity of Wisconsin-Madison600 Highland Ave., K6/562, Madison, WI 53792, USA,Carbone Cancer CenterUniversity of Wisconsin-MadisonMadison, WI 53705, USA;

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正文语种英语
中图分类无线电电子学、电信技术;工程材料学;
关键词
cancer theranostics; Cerenkov radiation; drug delivery; multimodal imaging; nanomaterials; positron emission tomography; semiconducting polymers;

Amplification of Cerenkov Luminescence Using Semiconducting Polymers for Cancer Theranostics

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