Peptide Polymer-Doped Cement Acting as an Effective Treatment of MRSA-Infected Chronic Osteomyelitis

Wu Yueming; Lin Yaofa; Cong ZihaoChen KangXiao XimianWu XueLiu LongqiangShe YunruiLiu ShiqiZhou RuiyiYin GangShao XiaoyanDai YidongLin HaodongLiu Runhui

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Peptide Polymer-Doped Cement Acting as an Effective Treatment of MRSA-Infected Chronic Osteomyelitis

机译：Peptide Polymer-Doped Cement Acting as an Effective Treatment of MRSA-Infected Chronic Osteomyelitis

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Chronic osteomyelitis is a painful and serious disease normally caused by infected surgical prostheses or infected fractures. Currently, antibiotic-loaded cements are extensively used as the treatment in clinical practice. However, the quick emergence of antibiotic-resistant bacteria has resulted in a formidable challenge in treating chronic osteomyelitis, such as the chronic osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA). Aiming to address MRSA-infected chronic osteomyelitis, an antibacterial peptide polymer doped polymethylmethacrylate bone cement pellets (PMMA@polymer) is prepared. The peptide polymer is designed as the synthetic mimic of host defense peptide and enables PMMA@polymer to have notable advantages, including complete release of antibacterial agent from PMMA, potent and robust activity against MRSA even after autoclave and enzymatic treatment, and low susceptibility to antibacterial resistance. PMMA@polymer showed potent in vitro activities against MRSA, superior in vivo therapeutic efficacy in a rabbit chronic osteomyelitis model, and low toxicity during the treatment. These advantages and the easy preparation of PMMA@polymer altogether suggest the great potential of PMMA@polymer as an effective treatment of MRSA-infected chronic osteomyelitis. This study opens new avenues in developing antibacterial biomaterials for the treatment of chronic orthopedic infections, frequently caused by drug-resistant bacteria.

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《Advanced functional materials》 |2022年第7期|2107942.1-2107942.10|共10页
作者
Wu Yueming; Lin Yaofa; Cong ZihaoChen KangXiao XimianWu XueLiu LongqiangShe YunruiLiu ShiqiZhou RuiyiYin GangShao XiaoyanDai YidongLin HaodongLiu Runhui;
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East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Frontiers Sci Ctr Materiobiol & Dynam Chem,Res Ct, Shanghai 200237, Peoples R China;

Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Orthoped Surg, Shanghai 200080, Peoples R China|Shanghai Gen Hosp, Jiading Branch, Shanghai 201803, Peoples R China;

Shanghai Ruijin Rehabil Hosp, Shanghai 200023, Peoples R ChinaEast China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China|East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Frontiers Sci Ctr Materiobiol & Dynam Chem,Res Ct, Shanghai 200237, Peoples R ChinaEast China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;

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antibacterial; chronic osteomyelitis; host defense peptides; MRSA; peptide polymers;

Peptide Polymer-Doped Cement Acting as an Effective Treatment of MRSA-Infected Chronic Osteomyelitis

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