Ultrastrong Poly(2-Oxazoline)/Poly(Acrylic Acid) Double-Network Hydrogels with Cartilage-Like Mechanical Properties

Paola A. Benitez-Duif; Marina Breisch; Daniel KurkaKarlina EdelSemra GoekcayDominic StangierWolfgang TillmannMontasser HijaziJoerg C. Tiller

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Ultrastrong Poly(2-Oxazoline)/Poly(Acrylic Acid) Double-Network Hydrogels with Cartilage-Like Mechanical Properties

机译：Ultrastrong Poly(2-Oxazoline)/Poly(Acrylic Acid) Double-Network Hydrogels with Cartilage-Like Mechanical Properties

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The exceptional stiffness and toughness of double-network hydrogels (DNHs) offer the possibility to mimic even complex biomaterials, such as cartilage. The latter has a limited regenerative capacity and thus needs to be substituted with an artificial material. DNHs composed of cross-linked poly(2- oxazoline)s (POx) and poly(acrylic acid) (PAA) are synthesized by free radical polymerization in a two-step process. The resulting DNHs are stabilized by hydrogen bridges even at pH 7.4 (physiological PBS buffer) due to the pKashifting effect of POx on PAA. DNHs based on poly(2-methyl-2-oxazoline), which have a water content (WC) of around 66 wt% and are not cytotoxic, show biomechanical properties that match those of cartilage in terms of WC, stiffness, toughness, coefficient of friction, compression in body relevant stress conditions and viscoelastic behavior. This material also has high strength in PBS pH 7.4 and in egg white as synovial liquid substitute. In particular, a compression strength of up to 60 MPa makes this material superior.

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《Advanced functional materials》 |2022年第44期|2204837.1-2204837.11|共11页
作者
Paola A. Benitez-Duif; Marina Breisch; Daniel KurkaKarlina EdelSemra GoekcayDominic StangierWolfgang TillmannMontasser HijaziJoerg C. Tiller;
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Institute of Materials Engineering TU Dortmund University Leonhard-Euler-Stra?e 2, 44227 Dortmund, Germany;

Biomaterials and Polymer Science Department of Bio- and Chemical Engineering TU Dortmund University Emil-Figge-Str. 66, 44227 Dortmund, Germany;

BG University Hospital Bergmannsheil Bochum Surgical Research Ruhr University Bochum Buerkle de la Camp Platz-1, 44789 Bochum, Germany;

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正文语种英语
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cartilage; double-network hydrogels; poly(2-oxazoline); poly(acrylic acid);

Ultrastrong Poly(2-Oxazoline)/Poly(Acrylic Acid) Double-Network Hydrogels with Cartilage-Like Mechanical Properties

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