Petromyzontidae-Biomimetic Multimodal Microneedles-Integrated Bioelectronic Catheters for Theranostic Endoscopic Surgery

Shuang Huang; Mengyi He; Chuanjie YaoXinshuo HuangDeyuan MaQiqi HuangJingbo YangFanmao LiuXingqiao WenJi WangHuijiuan ChenXi Xie

首页> 外文期刊>Advanced functional materials >Petromyzontidae-Biomimetic Multimodal Microneedles-Integrated Bioelectronic Catheters for Theranostic Endoscopic Surgery

【24h】

Petromyzontidae-Biomimetic Multimodal Microneedles-Integrated Bioelectronic Catheters for Theranostic Endoscopic Surgery

机译：Petromyzontidae-Biomimetic Multimodal Microneedles-Integrated Bioelectronic Catheters for Theranostic Endoscopic Surgery

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Current catheter devices in minimally invasive surgery still possess limitedfunctional options, lacking multimodal integration of both sensing andtherapy. Catheter devices usually operate outside the tissue, incapable todetect intra-tissue biochemical information for accurate localization andassessment of lesions during surgery. Inspired by the feature and functions ofPetromyzontidae, here a multimodal core-shell microneedles-integrated bioelectroniccatheter (MNIBC) for tissue-penetrating theranostics in endoscopicsurgery is developed. The microneedle (MN) device possesses individuallyaddressable functionality at single-MN tip resolution, enabling multiplexfunctions (a total of 11 functions distributed in three types of catheters)including biochemical sensing, myoelectric modulation, electroporation, anddrug delivery in a submucosal environment. The MNIBC is prepared throughhybrid fabrication and dimensionality reduction strategies, where the MNelectrodes are functionalized with an MXene-carbon nanotube (MXene-CNT)-based electron mediator, addressing the challenge of reduced electrode sensitivityon ultra-small MN tip. The functionalities of MNIBC are demonstratedboth ex vivo and in vivo on anesthetized rabbits via laparoscopy, simulatedcystoscopy, and laparotomy. The MNIBC can effectively detect intra-tissuebiochemical signals in the bladder, and offers localized electroporation andintra-tissue drug delivery for precise treatments of lesions. The versatile featuresof the MNIBC present a highly advanced platform for precise surgeries.

著录项

来源
《Advanced functional materials》 |2023年第15期|2214485.1-2214485.22|共22页
作者
Shuang Huang; Mengyi He; Chuanjie YaoXinshuo HuangDeyuan MaQiqi HuangJingbo YangFanmao LiuXingqiao WenJi WangHuijiuan ChenXi Xie;
展开▼
作者单位

State Key Laboratory of Optoelectronic Materials and TechnologiesGuangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510006, China;

The First Affiliated Hospital of Sun Yat-Sen UniversitySun Yat-Sen UniversityGuangzhou 510080, China;

The Third Affiliated Hospital of Sun Yat-Sen UniversitySun Yat-Sen UniversityGuangzhou 510630, ChinaState Key Laboratory of Optoelectronic Materials and TechnologiesGuangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510006, China, The First Affiliated Hospit;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
bioelectronic catheters; intra-tissue sensing; minimally invasive surgery; multimodal microneedle devices; Petromyzontidae-biomimetics;

Petromyzontidae-Biomimetic Multimodal Microneedles-Integrated Bioelectronic Catheters for Theranostic Endoscopic Surgery

摘要

著录项

相关主题

期刊订阅