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首页> 外文期刊>Advanced functional materials >Caffeic Acid-Deferoxamine Self-Polymerization Coating on Ti Implant Promotes Osteointegration by Synergetic Regulation of Multi-Pathways in ONFH Mechanism
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Caffeic Acid-Deferoxamine Self-Polymerization Coating on Ti Implant Promotes Osteointegration by Synergetic Regulation of Multi-Pathways in ONFH Mechanism

机译：Caffeic Acid-Deferoxamine Self-Polymerization Coating on Ti Implant Promotes Osteointegration by Synergetic Regulation of Multi-Pathways in ONFH Mechanism

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Osteonecrosis of the femoral head (ONFH) is a common but sophisticatedmultifactorial disease. In this study, the genomic characteristics of ONFHfrom the sequencing is first analyzed. Excepting ischemia and inflammation,some of differentially expressed genes (DEGs) are connected withautophagy. So, they are taken as the breakthrough points to design an autopolymerization coating of caffeic acid with grafting deferoxamine (DFO) andstrontium on Ti substrate. In vitro cells and in vivo immunofluorescenceand immunohistochemical results prove that the modified Ti can upregulatethe expression of HIF-1α in mesenchymal stem cells (MSCs) and humanumbilical vein endothelial cells (HUVECs) by receptors of TGF-β and TNFR oncell membrane. Interestingly, in MSCs, the upregulated HIF-1α can promoteautophagy to some extent by HIF-1α/BNIP2 pathway. Meanwhile, appropriateautophagy and HIF-1α can regulate MSCs proliferation and osteogenicdifferentiation by STAT3/Notch pathway. However, in HUVECs, althoughautophagy increases slightly, the upregulated HIF-1α prefers to increase itsdownstream target gene VEGF and accelerate angiogenesis by the pathwayof HIF-1α/VEGF. The results of in vivo implantation show that the modifiedTi substrate can effectively enhance the integration effect of the implant byosteogenesis and angiogenesis. More significantly, the modified Ti can retardthe further deterioration of ONFH by regulation of key genes.

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