The role of copper chromite nanoparticles on physical and bio properties of scaffolds based on poly(glycerol-azelaic acid) for application in tissue engineering fields

Heydari Masoumeh; Goodarzi Vahabodin; Shams MehdiKazemi Negar MotakefSalimi Ali

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The role of copper chromite nanoparticles on physical and bio properties of scaffolds based on poly(glycerol-azelaic acid) for application in tissue engineering fields

机译：The role of copper chromite nanoparticles on physical and bio properties of scaffolds based on poly(glycerol-azelaic acid) for application in tissue engineering fields

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Tissue engineering combines suitable cells, engineering methods, and proper biochemical factors to develop functional and biological tissues and repair damaged tissues. In this study, we focused on synthesizing and characterizing a nanocomposite scaffold based on glycerol and azelaic acid (Gl-Az) combined with copper chromite (CuCr2O4) nanoparticles in order to increase the osteogenic differentiation efficiency of human adipose-derived stem cells (hADSCs) on fabricated scaffolds. The degradability and hydrophobicity properties as well as mechanical and thermal behaviors of nanocomposite scaffolds were investigated. Next, the cell toxicity of glycerol, azelaic acid and CuCr2O4 nanoparticles was studied by MTT assay test and acridine orange staining. Finally, the osteogenic differentiation of hADSCs on Gl-Az-CuCr2O4 scaffolds was examined using alkaline phosphatase activity (ALP) and calcium content. The obtained results demonstrated that Gl-Az-1%CuCr2O4 not only showed appropriate mechanical strength, biocompatibility and degradability but also influenced the capability of hADSCs to differentiate into osteogenic lineages. The hADSCs culture in Gl-Az-1%CuCr2O4 showed a significant increase in ALP activity levels and calcium biomineralization after 14 days of osteogenic differentiation. In conclusion, the Gl-Az-1%CuCr2O4 nanocomposite could be used as a biocompatible and degradable scaffold to induce the bone differentiation of hADSCs and it could be a promising scaffold in bone regenerative medicine.

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来源
《Cell and Tissue Research》 |2023年第2期|357-373|共17页
作者
Heydari Masoumeh; Goodarzi Vahabodin; Shams MehdiKazemi Negar MotakefSalimi Ali;
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作者单位

Baqiyatallah University of Medical Sciences (BMSU),Baqiyatallah Univ Med Sci;

Nanobiotechnol Res Ctr,Baqiyatallah Univ Med Sci;

Dept Nanotechnol & Adv Mat,Mat & Energy Res Ctr;

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正文语种英语
中图分类细胞生物学;
关键词
Azelaic acid; Copper chromite; Glycerol; Osteogenic differentiation; Scaffold; Tissue engineering; BIOACTIVE GLASS NANOPARTICLES; OSTEOGENIC DIFFERENTIATION; THERMAL-DECOMPOSITION; CUCR2O4 NANOPARTICLES; BONE; CELLS; CATALYSTS; PROLIFERATION; DEGRADATION; OXIDATION;

The role of copper chromite nanoparticles on physical and bio properties of scaffolds based on poly(glycerol-azelaic acid) for application in tissue engineering fields

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