How Digestive Processes Can Affect the Bioavailability of PCBs Associated with Microplastics: A Modeling Study Supported by Empirical Data

Nor Nur Hazimah Mohamed; Niu Zhiyue; Hennebelle MarieKoelmans Albert A.

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How Digestive Processes Can Affect the Bioavailability of PCBs Associated with Microplastics: A Modeling Study Supported by Empirical Data

机译：How Digestive Processes Can Affect the Bioavailability of PCBs Associated with Microplastics: A Modeling Study Supported by Empirical Data

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The transfer kinetics of plastic-associated chemicalsduring intestinaldigestive processes is unknown. Here, we assessed whether digestiveprocesses affect chemical exchange kinetics on microplastics, usingan in vitro gut fluid digestive model mimicking thehuman upper intestinal tract. Chemical exchange kinetics of microplasticswere measured for 10 polychlorinated biphenyls (PCBs) as proxies forthe broad class of hydrophobic organic chemicals. Following earlierstudies, olive oil was used as a proxy for digestible food, underhigh and low digestive enzyme activities. The micelle-waterand oil-water partition coefficients of the 10 PCBs were alsodetermined to evaluate the relative contribution of each gut componentto sorb PCBs. A new biphasic and reversible chemical exchange model,which included the digestion process, fitted well to the empiricaldata. We demonstrate that the digestive processes that break downcontaminated food can lead to a substantial increase in chemical concentrationin microplastics by a factor of 10-20, thereby reducing theoverall chemical bioavailability in the gastrointestinal tract whencompared to a scenario without microplastics. Higher enzyme activitiesresult in more chemicals being released by the digested food, therebyresulting in higher chemical concentrations in the microplastics.While the model-calibrated kinetic parameters are specific to thestudied scenario, we argue that the mechanism of the reduced bioavailabilityof chemicals and the modeling tool developed have generic relevance.These digestive processes should be considered when assessing therisks of microplastics to humans and also biomagnification in aquaticfood webs. New biphasic and reversiblechemical exchange model withdigestion processes to understand the human health effects of microplastics.

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《Environmental Science & Technology: ES&T》 |2023年第31期|11452-11464|共13页
作者
Nor Nur Hazimah Mohamed; Niu Zhiyue; Hennebelle MarieKoelmans Albert A.;
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作者单位

Wageningen Univ & Res;

Nanyang Technol Univ;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
microplastics; hydrophobic organic chemicals; gut fluid; digestion; lipids; POLYCYCLIC AROMATIC-HYDROCARBONS; HYDROPHOBIC ORGANIC-CHEMICALS; POLYCHLORINATED-BIPHENYLS; SODIUM TAUROCHOLATE; FACILITATED TRANSPORT; ENHANCED DESORPTION; SORPTION; FOOD; ENVIRONMENT; SEDIMENT;

How Digestive Processes Can Affect the Bioavailability of PCBs Associated with Microplastics: A Modeling Study Supported by Empirical Data

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